Neuroscience

Anti-GPM6A Antibody (CAB9066)

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SKU:
CAB9066
Product Type:
Antibody
Applications:
WB
Applications:
IHC
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Neuroscience

Description

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Antibody Name:Anti-GPM6A Antibody
Antibody SKU:CAB9066
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GPM6A (NP_005268.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:U-87MG
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GPM6A (NP_005268.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEEN MEEG QTQK GCFE CCIK CLGG IPYA SLIA TILL YAGV ALFC GCGH EALS GTVN ILQT YFEM ARTA GDTL DVFT MIDI FKYV IYGI AAAF FVYG ILLM
Gene ID:2823
Uniprot:P51674
Cellular Location:Cell membrane, Cell projection, Multi-pass membrane protein, axon, dendritic spine, filopodium
Calculated MW:29kDa/30kDa/31kDa
Observed MW:31kDa
Synonyms:GPM6A, GPM6, M6A
Background:
UniProt Protein Function:GPM6A: Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G- protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor. Belongs to the myelin proteolipid protein family.
UniProt Protein Details:

Protein type:Cell surface; Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4q34.2

Cellular Component: cell soma; filopodium; neuron projection; plasma membrane

Molecular Function:protein binding

Biological Process: neurite morphogenesis; neuron migration; positive regulation of filopodium formation; stem cell differentiation; synaptogenesis

UniProt Code:P51674
NCBI GenInfo Identifier:2506889
NCBI Gene ID:2823
NCBI Accession:P51674.2
UniProt Secondary Accession:P51674,Q92602, B7Z642, E9PHI5,
UniProt Related Accession:P51674
Molecular Weight:31kDa
NCBI Full Name:Neuronal membrane glycoprotein M6-a
NCBI Synonym Full Names:glycoprotein M6A
NCBI Official Symbol:GPM6A  
NCBI Official Synonym Symbols:M6A; GPM6  
NCBI Protein Information:neuronal membrane glycoprotein M6-a
UniProt Protein Name:Neuronal membrane glycoprotein M6-a
Protein Family:Neuronal membrane glycoprotein
UniProt Gene Name:GPM6A  
Anti-GPM6A Polyclonal Antibody (CAB9066)Western blot analysis of extracts of U-87MG cells, using GPM6A antibody (CAB9066) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s.
Anti-GPM6A Polyclonal Antibody (CAB9066)Immunohistochemistry of paraffin-embedded mouse stomach using GPM6A antibody (CAB9066) at dilution of 1:100 (40x lens).
Anti-GPM6A Polyclonal Antibody (CAB9066)Immunohistochemistry of paraffin-embedded human stomach using GPM6A antibody (CAB9066) at dilution of 1:100 (40x lens).
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