Neuroscience
Anti-GPM6A Antibody (CAB12439)
- SKU:
- CAB12439
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Neuroscience
Description
| Antibody Name: | Anti-GPM6A Antibody |
| Antibody SKU: | CAB12439 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 159-278 of human GPM6A (NP_005268.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse eye, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 159-278 of human GPM6A (NP_005268.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | WTIC RNTT LVEG ANLC LDLR QFGI VTIG EEKK ICTV SENF LRMC ESTE LNMT FHLF IVAL AGAG AAVI AMVH YLMV LSAN WAYV KDAC RMQK YEDI KSKE EQEL HDIH STRS KERL NAYT |
| Gene ID: | 2823 |
| Uniprot: | P51674 |
| Cellular Location: | Cell membrane, Cell projection, Multi-pass membrane protein, axon, dendritic spine, filopodium |
| Calculated MW: | 29kDa/30kDa/31kDa |
| Observed MW: | 31kDa |
| Synonyms: | GPM6A, GPM6, M6A |
| Background: |
| UniProt Protein Function: | GPM6A: Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G- protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor. Belongs to the myelin proteolipid protein family. |
| UniProt Protein Details: | Protein type:Cell surface; Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 4q34.2 Cellular Component: cell soma; filopodium; neuron projection; plasma membrane Molecular Function:protein binding Biological Process: neurite morphogenesis; neuron migration; positive regulation of filopodium formation; stem cell differentiation; synaptogenesis |
| UniProt Code: | P51674 |
| NCBI GenInfo Identifier: | 2506889 |
| NCBI Gene ID: | 2823 |
| NCBI Accession: | P51674.2 |
| UniProt Secondary Accession: | P51674,Q92602, B7Z642, E9PHI5, |
| UniProt Related Accession: | P51674 |
| Molecular Weight: | 31kDa |
| NCBI Full Name: | Neuronal membrane glycoprotein M6-a |
| NCBI Synonym Full Names: | glycoprotein M6A |
| NCBI Official Symbol: | GPM6A |
| NCBI Official Synonym Symbols: | M6A; GPM6 |
| NCBI Protein Information: | neuronal membrane glycoprotein M6-a |
| UniProt Protein Name: | Neuronal membrane glycoprotein M6-a |
| Protein Family: | Neuronal membrane glycoprotein |
| UniProt Gene Name: | GPM6A |
 | Western blot analysis of extracts of various cell lines, using GPM6A antibody (CAB12439) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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