Name: Anti-GPIHBP1 Antibody (CAB13240)
Brand: Signal Transduction Antibodies 1
SKU: CAB13240
Availability: OutOfStock

Antibody Name:	Anti-GPIHBP1 Antibody
Antibody SKU:	CAB13240
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 50-151 of human GPIHBP1 (NP_835466.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human
Positive Samples:	U-87MG, LO2

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 50-151 of human GPIHBP1 (NP_835466.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	ETNR LPGG RSRV LLRC YTCK SLPR DERC NLTQ NCSH GQTC TTLI AHGN TESG LLTT HSTW CTDS CQPI TKTV EGTQ VTMT CCQS SLCN VPPW QSSR VQDP TG
Gene ID:	338328
Uniprot:	Q8IV16
Cellular Location:	Apical cell membrane, Basolateral cell membrane, Cell membrane, Extracellular side, GPI-anchor, Lipid-anchor, Peripheral membrane protein
Calculated MW:	19kDa
Observed MW:	20kDa

Synonyms:

GPIHBP1, GPI-HBP1, HYPL1D

Background:

This gene encodes a capillary endothelial cell protein that facilitates the lipolytic processing of triglyceride-rich lipoproteins. The encoded protein is a glycosylphosphatidylinositol-anchored protein that is a member of the lymphocyte antigen 6 (Ly6) family. This protein plays a major role in transporting lipoprotein lipase (LPL) from the subendothelial spaces to the capillary lumen. Mutations in this gene are the cause of hyperlipoproteinemia, type 1D. Alternate splicing results in multiple transcript variants.

UniProt Protein Function:	GPIHBP1: Plays a key role in the lipolytic processing of chylomicrons.
UniProt Protein Details:	Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 8q24.3 Cellular Component: anchored to external side of plasma membrane; apical plasma membrane; basolateral plasma membrane; external side of plasma membrane Molecular Function:protein transmembrane transporter activity Biological Process: cholesterol homeostasis; intracellular protein transport; positive regulation of lipoprotein lipase activity; protein import; protein stabilization; transcytosis Disease: Hyperlipoproteinemia, Type Id
NCBI Summary:	This gene encodes a capillary endothelial cell protein that facilitates the lipolytic processing of triglyceride-rich lipoproteins. The encoded protein is a glycosylphosphatidylinositol-anchored protein that is a member of the lymphocyte antigen 6 (Ly6) family. This protein plays a major role in transporting lipoprotein lipase (LPL) from the subendothelial spaces to the capillary lumen. Mutations in this gene are the cause of hyperlipoproteinemia, type 1D. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
UniProt Code:	Q8IV16
NCBI GenInfo Identifier:	684179339
NCBI Gene ID:	338328
NCBI Accession:	NP_001288701.1
UniProt Secondary Accession:	Q8IV16,Q6P3T2, Q86W15,
UniProt Related Accession:	Q8IV16
Molecular Weight:	19,806 Da
NCBI Full Name:	glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 isoform 2
NCBI Synonym Full Names:	glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
NCBI Official Symbol:	GPIHBP1
NCBI Official Synonym Symbols:	HYPL1D; GPI-HBP1
NCBI Protein Information:	glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1
UniProt Protein Name:	Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1
UniProt Synonym Protein Names:	High density lipoprotein-binding protein 1
Protein Family:	Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein
UniProt Gene Name:	GPIHBP1

Western blot analysis of extracts of various cell lines, using GPIHBP1 antibody (CAB13240) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

ELISA Kits

Human HDL / High-density lipoprotein ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)