Cell Biology Antibodies 5

Anti-GPD1L Antibody (CAB14392)

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SKU:
CAB14392
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GPD1L Antibody
Antibody SKU:CAB14392
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-351 of human GPD1L (NP_055956.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:293T, A-549, U-87MG, Mouse stomach, Mouse thymus, Mouse brain, Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-351 of human GPD1L (NP_055956.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAAA PLKV CIVG SGNW GSAV AKII GNNV KKLQ KFAS TVKM WVFE ETVN GRKL TDII NNDH ENVK YLPG HKLP ENVV AMSN LSEA VQDA DLLV FVIP HQFI HRIC DEIT GRVP KKAL GITL IKGI DEGP EGLK LISD IIRE KMGI DISV LMGA NIAN EVAA EKFC ETTI GSKV MENG LLFK ELLQ TPNF RITV VDDA DTVE LCGA LKNI VAVG AGFC DGLR CGDN TKAA VIRL GLME MIAF ARIF CKGQ VSTA TFLE SCGV ADLI TTCY GGRN RRVA EAFA RTGK TIEE LEKE MLNG QKLQ GPQT SAEV YRIL KQKG LLDK FPLF TAVY QICY ESRP VQEM LSCL QSHP EHT
Gene ID:23171
Uniprot:Q8N335
Cellular Location:Cytoplasm
Calculated MW:38kDa
Observed MW:38kDa
Synonyms:GPD1L, GPD1-L
Background:The protein encoded by this gene catalyzes the conversion of sn-glycerol 3-phosphate to glycerone phosphate. The encoded protein is found in the cytoplasm, associated with the plasma membrane, where it binds the sodium channel, voltage-gated, type V, alpha subunit (SCN5A). Defects in this gene are a cause of Brugada syndrome type 2 (BRS2) as well as sudden infant death syndrome (SIDS).
UniProt Protein Function:GPD1L: Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L. Defects in GPD1L are the cause of Brugada syndrome type 2 (BRGDA2). An autosomal dominant tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Defects in GPD1L are a cause of sudden infant death syndrome (SIDS). SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive. Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
UniProt Protein Details:

Protein type:Lipid Metabolism - glycerophospholipid; Oxidoreductase; EC 1.1.1.8

Chromosomal Location of Human Ortholog: 3p22.3

Cellular Component: cytosol; plasma membrane

Molecular Function:glycerol-3-phosphate dehydrogenase (NAD+) activity; sodium channel regulator activity

Biological Process: NAD metabolic process; negative regulation of peptidyl-serine phosphorylation; phosphatidic acid biosynthetic process; regulation of heart rate; triacylglycerol biosynthetic process

Disease: Brugada Syndrome 2

NCBI Summary:The protein encoded by this gene catalyzes the conversion of sn-glycerol 3-phosphate to glycerone phosphate. The encoded protein is found in the cytoplasm, associated with the plasma membrane, where it binds the sodium channel, voltage-gated, type V, alpha subunit (SCN5A). Defects in this gene are a cause of Brugada syndrome type 2 (BRS2) as well as sudden infant death syndrome (SIDS). [provided by RefSeq, Jul 2010]
UniProt Code:Q8N335
NCBI GenInfo Identifier:74750945
NCBI Gene ID:23171
NCBI Accession:Q8N335.1
UniProt Secondary Accession:Q8N335,Q14702, Q9BRM5, A8K9U3,
UniProt Related Accession:Q8N335
Molecular Weight:38,419 Da
NCBI Full Name:Glycerol-3-phosphate dehydrogenase 1-like protein
NCBI Synonym Full Names:glycerol-3-phosphate dehydrogenase 1-like
NCBI Official Symbol:GPD1L  
NCBI Official Synonym Symbols:GPD1-L  
NCBI Protein Information:glycerol-3-phosphate dehydrogenase 1-like protein
UniProt Protein Name:Glycerol-3-phosphate dehydrogenase 1-like protein
Protein Family:Glycerol-3-phosphate dehydrogenase 1-like protein
UniProt Gene Name:GPD1L  
UniProt Entry Name:GPD1L_HUMAN
Anti-GPD1L Antibody (CAB14392)Western blot analysis of extracts of various cell lines, using GPD1L antibody (CAB14392) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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