Cell Biology Antibodies 5
Anti-GPA33 Antibody (CAB15127)
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- SKU:
- CAB15127
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GPA33 Antibody |
| Antibody SKU: | CAB15127 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-235 of human GPA33 (NP_005805.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | mouse small intestine, rat small intestine |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-235 of human GPA33 (NP_005805.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ISVE TPQD VLRA SQGK SVTL PCTY HTST SSRE GLIQ WDKL LLTH TERV VIWP FSNK NYIH GELY KNRV SISN NAEQ SDAS ITID QLTM ADNG TYEC SVSL MSDL EGNT KSRV RLLV LVPP SKPE CGIE GETI IGNN IQLT CQSK EGSP TPQY SWKR YNIL NQEQ PLAQ PASG QPVS LKNI STDT SGYY ICTS SNEE GTQF CNIT VAVR SPSM NV |
| Gene ID: | 10223 |
| Uniprot: | Q99795 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 35kDa |
| Observed MW: | 45kDa |
| Synonyms: | GPA33, A33 |
| Background: | The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily. |
| UniProt Protein Function: | GPA33: May play a role in cell-cell recognition and signaling. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1q24.1 Cellular Component: integral to plasma membrane Molecular Function:receptor activity |
| NCBI Summary: | The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99795 |
| NCBI GenInfo Identifier: | 5031561 |
| NCBI Gene ID: | 10223 |
| NCBI Accession: | NP_005805.1 |
| UniProt Secondary Accession: | Q99795,Q5VZP6, |
| UniProt Related Accession: | Q99795 |
| Molecular Weight: | 35,632 Da |
| NCBI Full Name: | cell surface A33 antigen |
| NCBI Synonym Full Names: | glycoprotein A33 |
| NCBI Official Symbol: | GPA33 |
| NCBI Official Synonym Symbols: | A33 |
| NCBI Protein Information: | cell surface A33 antigen |
| UniProt Protein Name: | Cell surface A33 antigen |
| UniProt Synonym Protein Names: | Glycoprotein A33 |
| UniProt Gene Name: | GPA33 |
| UniProt Entry Name: | GPA33_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GPA33 antibody (CAB15127) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunofluorescence analysis of mouse colon using GPA33 antibody (CAB15127) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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