Name: Anti-GP6 Antibody (CAB14999)
Brand: Cardiovascular Antibodies
SKU: CAB14999
Availability: OutOfStock

Antibody Name:	Anti-GP6 Antibody
Antibody SKU:	CAB14999
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human GP6 (NP_057447.4).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human
Positive Samples:	Jurkat, human plasma

Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human GP6 (NP_057447.4).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	LVVT GTSV TPSR LPTE PPSP VAEF SEAT AELT VSFT NEVF TTET SRSI TASP KESD SPAG PARQ YYTK GNLV RICL GAVI LIIL AGFL AEDW HSRR KRLR HRGR AVQR PLPP LPPL PQTR KSHG GQDG GRQD VHSR GLCS
Gene ID:	51206
Uniprot:	Q9HCN6
Cellular Location:	Cell membrane, Single-pass membrane protein
Calculated MW:	35kDa/36kDa/67kDa
Observed MW:	55kDa

Synonyms:

GP6, BDPLT11, GPIV, GPVI

Background:

This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

UniProt Protein Function:	GPVI: Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma- chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. Defects in GP6 are the cause of bleeding disorder platelet-type 11 (BDPLT11). BDPLT11 is a mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.4 Cellular Component: cell surface; integral to plasma membrane; plasma membrane Molecular Function:collagen binding; protein binding; transmembrane receptor activity; receptor activity Biological Process: platelet activation; blood coagulation; leukocyte migration; enzyme linked receptor protein signaling pathway Disease: Bleeding Disorder, Platelet-type, 11
NCBI Summary:	This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
UniProt Code:	Q9HCN6
NCBI GenInfo Identifier:	26985217
NCBI Gene ID:	51206
NCBI Accession:	AAN86273.1
UniProt Secondary Accession:	Q9HCN6,Q9HCN7, Q9UIF2,
UniProt Related Accession:	Q9HCN6
Molecular Weight:	36,866 Da
NCBI Full Name:	glycoprotein VI, partial
NCBI Synonym Full Names:	glycoprotein VI (platelet)
NCBI Official Symbol:	GP6
NCBI Official Synonym Symbols:	GPIV; GPVI; BDPLT11
NCBI Protein Information:	platelet glycoprotein VI; glycoprotein 6; platelet collagen receptor
UniProt Protein Name:	Platelet glycoprotein VI
UniProt Synonym Protein Names:	Glycoprotein 6
Protein Family:	Platelet glycoprotein
UniProt Gene Name:	GP6
UniProt Entry Name:	GPVI_HUMAN

Western blot analysis of extracts of various cell lines, using GP6 antibody (CAB14999) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

ELISA Kits

Human Glycoprotein 6 / GP6 ELISA Kit

Human GP6 (Glycoprotein VI, Platelet) CLIA Kit (HUES01079)

Human Platelet glycoprotein VI (GP6) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)