Cell Biology Antibodies 9

Anti-GOSR2 Antibody (CAB4321)

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SKU:
CAB4321
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GOSR2 Antibody
Antibody SKU:CAB4321
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human GOSR2 (NP_004278.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:A-549, HT-29, MCF7, HT-1080, HepG2, K-562
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human GOSR2 (NP_004278.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDPL FQQT HKQV HEIQ SCMG RLET ADKQ SVHI VENE IQAS IDQI FSRL ERLE ILSS KEPP NKRQ NARL RVDQ LKYD VQHL QTAL RNFQ HRRH AREQ QERQ REEL LSRT FTTN DSDT TIPM DESL QFNS SLQK VHNG MDDL ILDG HNIL DGLR TQRL TLKG TQKK ILDI ANML GLSN TVMR LIEK RAFQ DK
Gene ID:9570
Uniprot:O14653
Cellular Location:Golgi apparatus, Golgi apparatus membrane, Single-pass type IV membrane protein, cis-Golgi network membrane
Calculated MW:22kDa/24kDa
Observed MW:24kDa
Synonyms:GOSR2, Bos1, EPM6, GS27
Background:This gene encodes a trafficking membrane protein which transports proteins among the medial- and trans-Golgi compartments. Due to its chromosomal location and trafficking function, this gene may be involved in familial essential hypertension.
UniProt Protein Function:GOSR2: Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network. Defects in GOSR2 are the cause of progressive myoclonic epilepsy type 6 (EPM6). A neurologic disorder characterized by onset of ataxia in the first years of life, followed by action myoclonus and seizures later in childhood, and loss of independent ambulation in the second decade. Cognition is not usually affected, although mild memory difficulties may occur in the third decade. Belongs to the GOSR2 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Endoplasmic reticulum; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: Golgi membrane; SNARE complex; Golgi apparatus; endoplasmic reticulum membrane; Golgi stack; membrane; late endosome membrane; integral to membrane

Molecular Function:SNAP receptor activity; SNARE binding; transporter activity

Biological Process: intra-Golgi vesicle-mediated transport; ER to Golgi vesicle-mediated transport; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; unfolded protein response; Golgi to vacuole transport; vesicle fusion with Golgi apparatus; protein targeting to vacuole; retrograde transport, endosome to Golgi

Disease: Epilepsy, Progressive Myoclonic 6

NCBI Summary:This gene encodes a trafficking membrane protein which transports proteins among the medial- and trans-Golgi compartments. Due to its chromosomal location and trafficking function, this gene may be involved in familial essential hypertension. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:O14653
NCBI GenInfo Identifier:22654242
NCBI Gene ID:9570
NCBI Accession:O14653.2
UniProt Secondary Accession:O14653,Q8N4B8, Q96DA5, Q9BZZ4, D3DXJ5, D3DXJ6,
UniProt Related Accession:O14653
Molecular Weight:212
NCBI Full Name:Golgi SNAP receptor complex member 2
NCBI Synonym Full Names:golgi SNAP receptor complex member 2
NCBI Official Symbol:GOSR2  
NCBI Official Synonym Symbols:Bos1; EPM6; GS27  
NCBI Protein Information:Golgi SNAP receptor complex member 2; membrin; 27 kDa Golgi SNARE protein
UniProt Protein Name:Golgi SNAP receptor complex member 2
UniProt Synonym Protein Names:27 kDa Golgi SNARE protein; Membrin
Protein Family:Golgi SNAP receptor complex
UniProt Gene Name:GOSR2  
UniProt Entry Name:GOSR2_HUMAN
Anti-GOSR2 Antibody (CAB4321)Western blot analysis of extracts of various cell lines, using GOSR2 antibody (CAB4321) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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