Metabolism Antibodies 1
Anti-GNPDA1 Antibody (CAB13717)
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- SKU:
- CAB13717
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-GNPDA1 Antibody |
| Antibody SKU: | CAB13717 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human GNPDA1 (NP_005462.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, OVCAR3, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human GNPDA1 (NP_005462.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MKLI ILEH YSQA SEWA AKYI RNRI IQFN PGPE KYFT LGLP TGST PLGC YKKL IEYY KNGD LSFK YVKT FN |
| Gene ID: | 10007 |
| Uniprot: | P46926 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 24kDa/32kDa |
| Observed MW: | 30-33kDa |
| Synonyms: | GNPDA1, GNP1, GNPDA, GNPI, GPI, HLN |
| Background: |
| UniProt Protein Function: | GNPDA1: Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo. Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - amino sugar and nucleotide sugar; Isomerase; EC 3.5.99.6; Hydrolase Chromosomal Location of Human Ortholog: 5q21 Cellular Component: cytoplasm Molecular Function:glucosamine-6-phosphate deaminase activity; hydrolase activity Biological Process: generation of precursor metabolites and energy; single fertilization; N-acetylglucosamine metabolic process; carbohydrate metabolic process; glucosamine catabolic process |
| NCBI Summary: | Glucosamine-6-phosphate deaminase (EC 3.5.99.6) is an allosteric enzyme that catalyzes the reversible conversion of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium (Arreola et al., 2003 [PubMed 12965206]).[supplied by OMIM, Jan 2010] |
| UniProt Code: | P46926 |
| NCBI GenInfo Identifier: | 1171639 |
| NCBI Gene ID: | 10007 |
| NCBI Accession: | P46926.1 |
| UniProt Related Accession: | P46926 |
| Molecular Weight: | Observed: 33 kDaPredicted: 33 kDa |
| NCBI Full Name: | Glucosamine-6-phosphate isomerase 1 |
| NCBI Synonym Full Names: | glucosamine-6-phosphate deaminase 1 |
| NCBI Official Symbol: | GNPDA1 |
| NCBI Official Synonym Symbols: | GPI; HLN; GNP1; GNPI; GNPDA |
| NCBI Protein Information: | glucosamine-6-phosphate isomerase 1 |
| UniProt Protein Name: | Glucosamine-6-phosphate isomerase 1 |
| UniProt Synonym Protein Names: | Glucosamine-6-phosphate deaminase 1; GNPDA 1; GlcN6P deaminase 1; Oscillin |
| Protein Family: | Glucosamine-6-phosphate isomerase |
| UniProt Gene Name: | GNPDA1 |
| UniProt Entry Name: | GNPI1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GNPDA1 antibody (CAB13717) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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