Cell Biology Antibodies 12

Anti-GNG3 Antibody (CAB9817)

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SKU:
CAB9817
Product Type:
Antibody
Applications:
WB
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GNG3 Antibody
Antibody SKU:CAB9817
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-75 of human GNG3 (NP_036334.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-75 of human GNG3 (NP_036334.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MKGE TPVN STMS IGQA RKMV EQLK IEAS LCRI KVSK AAAD LMTY CDAH ACED PLIT PVPT SENP FREK KFFC ALL
Gene ID:2785
Uniprot:P63215
Cellular Location:Cell membrane, Cytoplasmic side, Lipid-anchor
Calculated MW:8kDa
Observed MW:14kDa
Synonyms:GNG3
Background:Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The gamma subunit determines the specificity of which signaling pathways will be affected by this particular complex. The protein encoded by this gene represents the gamma subunit of both inhibitory and stimulatory complexes.
UniProt Protein Function:G-gamma 3: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Belongs to the G protein gamma family.
UniProt Protein Details:

Protein type:G protein, heterotrimeric gamma; G protein, heterotrimeric; G protein

Chromosomal Location of Human Ortholog: 11p11

Cellular Component: plasma membrane

Molecular Function:GTPase activity

Biological Process: activation of MAPK activity

NCBI Summary:Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The gamma subunit determines the specificity of which signaling pathways will be affected by this particular complex. The protein encoded by this gene represents the gamma subunit of both inhibitory and stimulatory complexes. [provided by RefSeq, Jan 2012]
UniProt Code:P63215
NCBI GenInfo Identifier:52783596
NCBI Gene ID:2785
NCBI Accession:P63215.1
UniProt Secondary Accession:P63215,P29798, Q61014, B2R4S7,
UniProt Related Accession:P63215
Molecular Weight:8,305 Da
NCBI Full Name:Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
NCBI Synonym Full Names:G protein subunit gamma 3
NCBI Official Symbol:GNG3  
NCBI Protein Information:guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
UniProt Protein Name:Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
UniProt Gene Name:GNG3  
UniProt Entry Name:GBG3_HUMAN
Anti-GNG3 Polyclonal Antibody (CAB9817)Western blot analysis of extracts of various cell lines, using GNG3 antibody (CAB9817) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s.
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