Cell Biology Antibodies 1

Anti-GNG2 Antibody (CAB10309)

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SKU:
CAB10309
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GNG2 Antibody
Antibody SKU:CAB10309
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-71 of human GNG2 (NP_444292.1).
Application:WB IHC
Recommended Dilution:WB 1:1000 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:A-431, Mouse lung, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-71 of human GNG2 (NP_444292.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MASN NTAS IAQA RKLV EQLK MEAN IDRI KVSK AAAD LMAY CEAH AKED PLLT PVPA SENP FREK KFFC AIL
Gene ID:54331
Uniprot:P59768
Cellular Location:Cell membrane, Cytoplasmic side, Lipid-anchor
Calculated MW:7kDa
Observed MW:8kDa
Synonyms:GNG2
Background:This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules.
UniProt Protein Function:G-gamma 2: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Belongs to the G protein gamma family.
UniProt Protein Details:

Protein type:G protein; G protein, heterotrimeric; G protein, heterotrimeric gamma

Chromosomal Location of Human Ortholog: 14q22.1

Cellular Component: heterotrimeric G-protein complex; membrane; plasma membrane

Molecular Function:G-protein beta-subunit binding

Biological Process: dopamine receptor, adenylate cyclase activating pathway; platelet activation; protein folding; Wnt receptor signaling pathway, calcium modulating pathway

NCBI Summary:This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules. [provided by RefSeq, Aug 2011]
UniProt Code:P59768
NCBI GenInfo Identifier:32699499
NCBI Gene ID:54331
NCBI Accession:P59768.2
UniProt Secondary Accession:P59768,Q5JPE2, Q6P9A9,
UniProt Related Accession:P59768
Molecular Weight:8kDa
NCBI Full Name:Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
NCBI Synonym Full Names:G protein subunit gamma 2
NCBI Official Symbol:GNG2  
NCBI Protein Information:guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
UniProt Protein Name:Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
UniProt Synonym Protein Names:G gamma-I
UniProt Gene Name:GNG2  
Anti-GNG2 Antibody (CAB10309)Western blot analysis of extracts of various cell lines, using GNG2 antibody (CAB10309) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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