Cell Biology Antibodies 3
Anti-GNB4 Antibody (CAB12731)
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- SKU:
- CAB12731
Description
| Antibody Name: | Anti-GNB4 Antibody |
| Antibody SKU: | CAB12731 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-340 of human GNB4 (NP_067642.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: | U-87MG, A-375 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-340 of human GNB4 (NP_067642.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSEL EQLR QEAE QLRN QIQD ARKA CNDA TLVQ ITSN MDSV GRIQ MRTR RTLR GHLA KIYA MHWG YDSR LLVS ASQD GKLI IWDS YTTN KMHA IPLR SSWV MTCA YAPS GNYV ACGG LDNI CSIY NLKT REGN VRVS RELP GHTG YLSC CRFL DDSQ IVTS SGDT TCAL WDIE TAQQ TTTF TGHS GDVM SLSL SPDM RTFV SGAC DASS KLWD IRDG MCRQ SFTG HVSD INAV SFFP NGYA FATG SDDA TCRL FDLR ADQE LLLY SHDN IICG ITSV AFSK SGRL LLAG YDDF NCNV WDTL KGDR AGVL AGHD NRVS CLGV TDDG MAVA TGSW DSFL RIWN |
| Gene ID: | 59345 |
| Uniprot: | Q9HAV0 |
| Cellular Location: | |
| Calculated MW: | 37kDa |
| Observed MW: | 38kDa |
| Synonyms: | GNB4, CMTD1F |
| Background: | Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. |
| UniProt Protein Function: | G-beta 4: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Belongs to the WD repeat G protein beta family. |
| UniProt Protein Details: | Protein type:G protein, heterotrimeric beta; G protein, heterotrimeric; Membrane protein, peripheral Chromosomal Location of Human Ortholog: 3q26.33 Cellular Component: cytosol; lysosomal membrane; plasma membrane Molecular Function:protein complex binding Biological Process: protein folding; substantia nigra development Disease: Charcot-marie-tooth Disease, Dominant Intermediate F |
| NCBI Summary: | Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9HAV0 |
| NCBI GenInfo Identifier: | 22256759 |
| NCBI Gene ID: | 59345 |
| NCBI Accession: | Q9HAV0.3 |
| UniProt Secondary Accession: | Q9HAV0,B3KMH5, D3DNR8, |
| UniProt Related Accession: | Q9HAV0 |
| Molecular Weight: | 37,567 Da |
| NCBI Full Name: | Guanine nucleotide-binding protein subunit beta-4 |
| NCBI Synonym Full Names: | G protein subunit beta 4 |
| NCBI Official Symbol: | GNB4 |
| NCBI Official Synonym Symbols: | CMTD1F |
| NCBI Protein Information: | guanine nucleotide-binding protein subunit beta-4 |
| UniProt Protein Name: | Guanine nucleotide-binding protein subunit beta-4 |
| UniProt Synonym Protein Names: | Transducin beta chain 4 |
| Protein Family: | Guanine nucleotide-binding protein |
| UniProt Gene Name: | GNB4 |
| UniProt Entry Name: | GBB4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GNB4 antibody (CAB12731) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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Additional Information
Product Type: |
Antibody |
Reactivity: |
Human |
Reactivity: |
Rat |
Host Species: |
Rabbit |
Isotype: |
IgG |
Antibody Type: |
Polyclonal Antibody |
Research Area: |
Cell Biology |
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