Cell Death Antibodies 1
Anti-GNB2L1 Antibody (CAB0151)
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- SKU:
- CAB0151
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-GNB2L1 Antibody |
| Antibody SKU: | CAB0151 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-290 of human GNB2L1 (NP_006089.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | MCF7, 293T, Mouse spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-290 of human GNB2L1 (NP_006089.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MILS ASRD KTII MWKL TRDE TNYG IPQR ALRG HSHF VSDV VISS DGQF ALSG SWDG TLRL WDLT TGTT TRRF VGHT KDVL SVAF SSDN RQIV SGSR DKTI KLWN TLGV CKYT VQDE SHSE WVSC VRFS PNSS NPII VSCG WDKL VKVW NLAN CKLK TNHI GHTG YLNT VTVS PDGS LCAS GGKD GQAM LWDL NEGK HLYT LDGG DIIN ALCF SPNR YWLC AATG PSIK IWDL EGKI IVDE LKQE VIST SSKA EPPQ CTSL A |
| Gene ID: | 10399 |
| Uniprot: | P63244 |
| Cellular Location: | Cell membrane, Cell projection, Cytoplasm, Nucleus, Perikaryon, Peripheral membrane protein, cytoskeleton, dendrite, perinuclear region, phagocytic cup |
| Calculated MW: | 35kDa |
| Observed MW: | 35kDa |
| Synonyms: | RACK1, GNB2L1, Gnb2-rs1, H12.3, HLC-7, PIG21 |
| Background: |
| UniProt Protein Function: | Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:23636399). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (PubMed:28132843). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (PubMed:19674157). Promotes migration of breast carcinoma cells by binding to and activating RHOA (PubMed:20499158). |
| UniProt Code: | P63244 |
| NCBI GenInfo Identifier: | 54037168 |
| NCBI Gene ID: | 10399 |
| NCBI Accession: | P63244.3 |
| UniProt Secondary Accession: | P63244,P25388, P99049, Q53HU2, Q5J8M6, Q5VLR4, Q6FH47 B3KTJ0, D3DWS0, |
| UniProt Related Accession: | P63244 |
| Molecular Weight: | 35,077 Da |
| NCBI Full Name: | Receptor of activated protein C kinase 1 |
| NCBI Synonym Full Names: | receptor for activated C kinase 1 |
| NCBI Official Symbol: | RACK1 |
| NCBI Official Synonym Symbols: | H12.3; HLC-7; PIG21; GNB2L1; Gnb2-rs1 |
| NCBI Protein Information: | receptor of activated protein C kinase 1 |
| UniProt Protein Name: | Receptor of activated protein C kinase 1 |
| UniProt Synonym Protein Names: | Receptor of activated protein C kinase 1, N-terminally processedAlternative name(s):Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed |
| UniProt Gene Name: | RACK1 |
 | Western blot analysis of extracts of various cell lines, using GNB2L1 antibody (CAB0151) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded human oophoroma using GNB2L1 antibody (CAB0151) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of A-549 cells using GNB2L1 antibody (CAB0151). Blue: DAPI for nuclear staining. |
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