Cell Biology Antibodies 11

Anti-GNB1L Antibody (CAB7810)

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SKU:
CAB7810
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GNB1L Antibody
Antibody SKU:CAB7810
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-327 of human GNB1L (NP_443730.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, MCF7, SW620, A-549, Mouse brain, Mouse heart, Mouse testis, Mouse thymus, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-327 of human GNB1L (NP_443730.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MTAP CPPP PPDP QFVL RGTQ SPVH ALHF CEGA QAQG RPLL FSGS QSGL VHIW SLQT RRAV TTLD GHGG QCVT WLQT LPQG RQLL SQGR DLKL CLWD LAEG RSAV VDSV CLES VGFC RSSI LAGG QPRW TLAV PGRG SDEV QILE MPSK TSVC ALKP KADA KLGM PMCL RLWQ ADCS SRPL LLAG YEDG SVVL WDVS EQKV CSRI ACHE EPVM DLDF DSQK ARGI SGSA GKAL AVWS LDWQ QALQ VRGT HELT NPGI AEVT IRPD RKIL ATAG WDHR IRVF HWRT MQPL AVLA FHSA AVQC VAFT ADGL LAAG SKDQ RISL WSLY PRA
Gene ID:54584
Uniprot:Q9BYB4
Cellular Location:
Calculated MW:22kDa/35kDa
Observed MW:35kDa
Synonyms:GNB1L, DGCRK3, FKSG1, GY2, WDR14, WDVCF
Background:This gene encodes a G-protein beta-subunit-like polypeptide which is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 6 WD repeats and is highly expressed in the heart. The gene maps to the region on chromosome 22q11, which is deleted in DiGeorge syndrome, trisomic in derivative 22 syndrome and tetrasomic in cat-eye syndrome. Therefore, this gene may contribute to the etiology of those disorders. Transcripts from this gene share exons with some transcripts from the C22orf29 gene.
UniProt Protein Function:GNB1L: 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 22q11.2

Cellular Component: internal side of plasma membrane; cytoplasm

Biological Process: G-protein coupled receptor protein signaling pathway; social behavior

NCBI Summary:This gene encodes a G-protein beta-subunit-like polypeptide which is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 6 WD repeats and is highly expressed in the heart. The gene maps to the region on chromosome 22q11, which is deleted in DiGeorge syndrome, trisomic in derivative 22 syndrome and tetrasomic in cat-eye syndrome. Therefore, this gene may contribute to the etiology of those disorders. Transcripts from this gene share exons with some transcripts from the C22orf29 gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q9BYB4
NCBI GenInfo Identifier:17402902
NCBI Gene ID:54584
NCBI Accession:NP_443730.1
UniProt Secondary Accession:Q9BYB4,Q9H2S2, Q9H4M4,
UniProt Related Accession:Q9BYB4
Molecular Weight:22,896 Da
NCBI Full Name:guanine nucleotide-binding protein subunit beta-like protein 1
NCBI Synonym Full Names:guanine nucleotide binding protein (G protein), beta polypeptide 1-like
NCBI Official Symbol:GNB1L  
NCBI Official Synonym Symbols:GY2; FKSG1; WDR14; WDVCF; DGCRK3  
NCBI Protein Information:guanine nucleotide-binding protein subunit beta-like protein 1
UniProt Protein Name:Guanine nucleotide-binding protein subunit beta-like protein 1
UniProt Synonym Protein Names:DGCRK3; WD repeat-containing protein 14; WD40 repeat-containing protein deleted in VCFS; WDVCF
Protein Family:Guanine nucleotide-binding protein subunit beta-like protein
UniProt Gene Name:GNB1L  
UniProt Entry Name:GNB1L_HUMAN
Anti-GNB1L Antibody (CAB7810)Western blot analysis of extracts of various cell lines, using GNB1L antibody (CAB7810) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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