Cell Biology Antibodies 5
Anti-GNAZ Antibody (CAB14737)
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- SKU:
- CAB14737
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GNAZ Antibody |
| Antibody SKU: | CAB14737 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human GNAZ (NP_002064.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, SH-SY5Y, Mouse brain, Rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human GNAZ (NP_002064.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LFDS ICNN NWFI NTSL ILFL NKKD LLAE KIRR IPLT ICFP EYKG QNTY EEAA VYIQ RQFE DLNR NKET KEIY SHFT CATD TSNI QFVF DAVT DVII QNNL K |
| Gene ID: | 2781 |
| Uniprot: | P19086 |
| Cellular Location: | Lipid-anchor, Membrane |
| Calculated MW: | 40kDa |
| Observed MW: | 41kDa |
| Synonyms: | GNAZ, gz-alpha |
| Background: | The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids. |
| UniProt Protein Function: | G-alpha(z): Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Belongs to the G-alpha family. G(i/o/t/z) subfamily. |
| UniProt Protein Details: | Protein type:Nuclear envelope; Endoplasmic reticulum; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z)) Chromosomal Location of Human Ortholog: 22q11.22 Cellular Component: endoplasmic reticulum; plasma membrane; heterotrimeric G-protein complex; nuclear envelope; cytosol Molecular Function:GTPase activity; signal transducer activity; GTP binding; metal ion binding; G-protein beta/gamma-subunit binding; receptor signaling protein activity; metabotropic serotonin receptor binding Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; metabolic process; G-protein signaling, adenylate cyclase inhibiting pathway |
| NCBI Summary: | The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P19086 |
| NCBI GenInfo Identifier: | 121005 |
| NCBI Gene ID: | 2781 |
| NCBI Accession: | P19086.3 |
| UniProt Secondary Accession: | P19086,Q4QRJ6, B2R6C1, |
| UniProt Related Accession: | P19086 |
| Molecular Weight: | 355 |
| NCBI Full Name: | Guanine nucleotide-binding protein G(z) subunit alpha |
| NCBI Synonym Full Names: | guanine nucleotide binding protein (G protein), alpha z polypeptide |
| NCBI Official Symbol: | GNAZ |
| NCBI Protein Information: | guanine nucleotide-binding protein G(z) subunit alpha; guanine nucleotide-binding protein G(z) subunit alpha; gz-alpha; g(x) alpha chain; transducin alpha |
| UniProt Protein Name: | Guanine nucleotide-binding protein G(z) subunit alpha |
| UniProt Synonym Protein Names: | G(x) alpha chain; Gz-alpha |
| UniProt Gene Name: | GNAZ |
| UniProt Entry Name: | GNAZ_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GNAZ antibody (CAB14737) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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