Cell Biology Antibodies 4

Anti-GNAZ Antibody (CAB13991)

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SKU:
CAB13991
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GNAZ Antibody
Antibody SKU:CAB13991
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human GNAZ
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain
Immunogen:Recombinant protein of human GNAZ
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2781
Uniprot:P19086
Cellular Location:Lipid-anchor, Membrane
Calculated MW:40kDa
Observed MW:37kDa
Synonyms:GNAZ, gz-alpha
Background:The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids.
UniProt Protein Function:G-alpha(z): Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Belongs to the G-alpha family. G(i/o/t/z) subfamily.
UniProt Protein Details:

Protein type:Nuclear envelope; Endoplasmic reticulum; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z))

Chromosomal Location of Human Ortholog: 22q11.22

Cellular Component: endoplasmic reticulum; plasma membrane; heterotrimeric G-protein complex; nuclear envelope; cytosol

Molecular Function:GTPase activity; signal transducer activity; GTP binding; metal ion binding; G-protein beta/gamma-subunit binding; receptor signaling protein activity; metabotropic serotonin receptor binding

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; metabolic process; G-protein signaling, adenylate cyclase inhibiting pathway

NCBI Summary:The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids. [provided by RefSeq, Jul 2008]
UniProt Code:P19086
NCBI GenInfo Identifier:121005
NCBI Gene ID:2781
NCBI Accession:P19086.3
UniProt Secondary Accession:P19086,Q4QRJ6, B2R6C1,
UniProt Related Accession:P19086
Molecular Weight:355
NCBI Full Name:Guanine nucleotide-binding protein G(z) subunit alpha
NCBI Synonym Full Names:guanine nucleotide binding protein (G protein), alpha z polypeptide
NCBI Official Symbol:GNAZ  
NCBI Protein Information:guanine nucleotide-binding protein G(z) subunit alpha; guanine nucleotide-binding protein G(z) subunit alpha; gz-alpha; g(x) alpha chain; transducin alpha
UniProt Protein Name:Guanine nucleotide-binding protein G(z) subunit alpha
UniProt Synonym Protein Names:G(x) alpha chain; Gz-alpha
UniProt Gene Name:GNAZ  
UniProt Entry Name:GNAZ_HUMAN
Anti-GNAZ Antibody (CAB13991)Western blot analysis of extracts of mouse brain, using GNAZ antibody (CAB13991) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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