Name: Anti-GNAT2 Antibody (CAB10352)
Brand: Signal Transduction Antibodies 1
SKU: CAB10352
Availability: OutOfStock

Antibody Name:	Anti-GNAT2 Antibody
Antibody SKU:	CAB10352
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human GNAT2 (NP_005263.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human
Positive Samples:	HepG2

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human GNAT2 (NP_005263.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MGSG ASAE DKEL AKRS KELE KKLQ EDAD KEAK TVKL LLLG AGES GKST IVKQ MKII HQDG YSPE ECLE FKAI IYGN VLQS ILAI IRAM TTLG IDYA EPSC ADDG RQLN NLAD SIEE GTMP PELV EVIR RLWK DGGV QACF ERAA EYQL NDSA SYYL NQLE RITD PEYL PSEQ DVLR SRVK TTGI IETK FSVK DLNF RMFD VGGQ RSER KKWI HCFE GVTC
Gene ID:	2780
Uniprot:	P19087
Cellular Location:
Calculated MW:	40kDa
Observed MW:	45kDa

Synonyms:	GNAT2, ACHM4, GNATC
Background:	Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones.

UniProt Protein Function:	G-alpha t2: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. Defects in GNAT2 are the cause of achromatopsia type 4 (ACHM4). Achromatopsia is an autosomal recessively inherited visual disorder that is present from birth and that features the absence of color discrimination. Belongs to the G-alpha family. G(i/o/t/z) subfamily.
UniProt Protein Details:	Protein type:G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z)); G protein Chromosomal Location of Human Ortholog: 1p13.1 Cellular Component: heterotrimeric G-protein complex; photoreceptor inner segment; photoreceptor outer segment; plasma membrane Molecular Function:G-protein beta/gamma-subunit binding; G-protein-coupled receptor binding; GTP binding; GTPase activity; signal transducer activity Biological Process: detection of chemical stimulus involved in sensory perception of bitter taste; detection of light stimulus involved in visual perception; G-protein signaling, coupled to cAMP nucleotide second messenger; protein folding; Wnt receptor signaling pathway, calcium modulating pathway Disease: Achromatopsia 4
NCBI Summary:	Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones. [provided by RefSeq, Jul 2008]
UniProt Code:	P19087
NCBI GenInfo Identifier:	232151
NCBI Gene ID:	2780
NCBI Accession:	P19087.4
UniProt Related Accession:	P19087
Molecular Weight:	40,176 Da
NCBI Full Name:	Guanine nucleotide-binding protein G(t) subunit alpha-2
NCBI Synonym Full Names:	G protein subunit alpha transducin 2
NCBI Official Symbol:	GNAT2
NCBI Official Synonym Symbols:	ACHM4; GNATC
NCBI Protein Information:	guanine nucleotide-binding protein G(t) subunit alpha-2
UniProt Protein Name:	Guanine nucleotide-binding protein G(t) subunit alpha-2
UniProt Synonym Protein Names:	Transducin alpha-2 chain
UniProt Gene Name:	GNAT2
UniProt Entry Name:	GNAT2_HUMAN

Western blot analysis of extracts of HepG2 cells, using GNAT2 antibody (CAB10352) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.

Antibodies

GNAT2 Antibody (PACO03907)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)