Name: Anti-GNAL Antibody (CAB12868)
Brand: Cell Biology Antibodies 3
SKU: CAB12868
Availability: OutOfStock

Antibody Name:	Anti-GNAL Antibody
Antibody SKU:	CAB12868
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human GNAL (NP_892023.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse, Rat
Positive Samples:	Mouse kidney, Rat brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human GNAL (NP_892023.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MGLC YSLR PLLF GGPG DDPC AASE PPVE DAQP APAP ALAP VRAA ARDT ARTL LPRG GEGS PACA RPKA DKPK EKRQ RTEQ LSAE EREA AKER EAVK EARK VSRG IDRM LRDQ KRDL QQTH
Gene ID:	2774
Uniprot:	P38405
Cellular Location:
Calculated MW:	20kDa/44kDa/52kDa
Observed MW:	44kDa

Synonyms:

GNAL, DYT25

Background:

This gene encodes a stimulatory G protein alpha subunit which mediates odorant signaling in the olfactory epithelium. This protein couples dopamine type 1 receptors and adenosine A2A receptors and is widely expressed in the central nervous system. Mutations in this gene have been associated with dystonia 25 and this gene is located in a susceptibility region for bipolar disorder and schizophrenia. Alternative splicing results in multiple transcript variants.

UniProt Protein Function:	G-alpha(olf): Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters. Belongs to the G-alpha family. G(s) subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:G protein, heterotrimeric alpha G(s); Membrane protein, peripheral; G protein, heterotrimeric Chromosomal Location of Human Ortholog: 18p11.22-p11.21 Cellular Component: plasma membrane Molecular Function:G-protein beta/gamma-subunit binding; GTP binding; GTPase activity; metal ion binding; signal transducer activity Biological Process: adenylate cyclase activation; dopamine receptor, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; metabolic process; response to amphetamine; response to caffeine; sensory perception of smell; signal transduction; synaptic transmission Disease: Dystonia 25
NCBI Summary:	This gene encodes a stimulatory G protein alpha subunit which mediates odorant signaling in the olfactory epithelium. This protein couples dopamine type 1 receptors and adenosine A2A receptors and is widely expressed in the central nervous system. Mutations in this gene have been associated with dystonia 25 and this gene is located in a susceptibility region for bipolar disorder and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
UniProt Code:	P38405
NCBI GenInfo Identifier:	585178
NCBI Gene ID:	2774
NCBI Accession:	P38405.1
UniProt Secondary Accession:	P38405,Q86XU3, B7ZA26,
UniProt Related Accession:	P38405
Molecular Weight:	20,522 Da
NCBI Full Name:	Guanine nucleotide-binding protein G(olf) subunit alpha
NCBI Synonym Full Names:	G protein subunit alpha L
NCBI Official Symbol:	GNAL
NCBI Official Synonym Symbols:	DYT25
NCBI Protein Information:	guanine nucleotide-binding protein G(olf) subunit alpha
UniProt Protein Name:	Guanine nucleotide-binding protein G(olf) subunit alpha
UniProt Synonym Protein Names:	Adenylate cyclase-stimulating G alpha protein, olfactory type
UniProt Gene Name:	GNAL
UniProt Entry Name:	GNAL_HUMAN

Western blot analysis of extracts of various cell lines, using GNAL antibody (CAB12868) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.

Antibodies

Anti-GNAL Antibody (CAB12804)

GNAL Antibody (PACO06535)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)