Metabolism Antibodies 1
Anti-GMPR Antibody (CAB12292)
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- SKU:
- CAB12292
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-GMPR Antibody |
| Antibody SKU: | CAB12292 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-120 of human GMPR (NP_006868.3). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T, K-562, Mouse heart, Mouse kidney, Mouse spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-120 of human GMPR (NP_006868.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TFEM AAVM SQHS MFTA IHKH YSLD DWKL FATN HPEC LQNV AVSS GSGQ NDLE KMTS ILEA V |
| Gene ID: | 2766 |
| Uniprot: | P36959 |
| Cellular Location: | |
| Calculated MW: | 37kDa |
| Observed MW: | 37kDa |
| Synonyms: | GMPR, GMPR 1, GMPR1 |
| Background: | This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides. |
| UniProt Protein Function: | GMPR: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Belongs to the IMPDH/GMPR family. |
| UniProt Protein Details: | Protein type:Nucleotide Metabolism - purine; EC 1.7.1.7; Oxidoreductase Chromosomal Location of Human Ortholog: 6p23 Cellular Component: cytosol Molecular Function:GMP reductase activity; metal ion binding Biological Process: nucleobase, nucleoside and nucleotide metabolic process; nucleotide metabolic process; response to cold; purine base metabolic process; purine salvage |
| NCBI Summary: | This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides.[provided by RefSeq, Oct 2009] |
| UniProt Code: | P36959 |
| NCBI GenInfo Identifier: | 544455 |
| NCBI Gene ID: | 2766 |
| NCBI Accession: | P36959.1 |
| UniProt Secondary Accession: | P36959,Q96HQ6, |
| UniProt Related Accession: | P36959 |
| Molecular Weight: | 37,419 Da |
| NCBI Full Name: | GMP reductase 1 |
| NCBI Synonym Full Names: | guanosine monophosphate reductase |
| NCBI Official Symbol: | GMPR |
| NCBI Official Synonym Symbols: | GMPR1 |
| NCBI Protein Information: | GMP reductase 1; guanine monophosphate reductase; guanosine 5'-monophosphate oxidoreductase 1; guanosine monophosphate reductase 1 |
| UniProt Protein Name: | GMP reductase 1 |
| UniProt Synonym Protein Names: | Guanosine 5'-monophosphate oxidoreductase 1; Guanosine monophosphate reductase 1 |
| Protein Family: | GMP reductase |
| UniProt Gene Name: | GMPR |
| UniProt Entry Name: | GMPR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GMPR antibody (CAB12292) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human placenta using GMPR antibody (CAB12292) at dilution of 1:100 (40x lens). |
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