Signal Transduction Antibodies 2
Anti-GMPPB Antibody (CAB16520)
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- SKU:
- CAB16520
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-GMPPB Antibody |
| Antibody SKU: | CAB16520 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-250 of human GMPPB (NP_068806.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse thymus, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-250 of human GMPPB (NP_068806.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ILAV SYMS QVLE KEMK AQEQ RLGI RISM SHEE EPLG TAGP LALA RDLL SETA DPFF VLNS DVIC DFPF QAMV QFHR HHGQ EGSI LVTK VEEP SKYG VVVC EADT GRIH RFVE KPQV FVSN KINA GMYI LSPA VLRR IQLQ PTSI EKEV FPIM AKEG QLYA MELQ GFWM DIGQ PKDF LTGM CLFL QSLR QKQP ERLC SGPG I |
| Gene ID: | 29925 |
| Uniprot: | Q9Y5P6 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 39kDa/42kDa |
| Observed MW: | 41kDa |
| Synonyms: | GMPPB, MDDGA14, MDDGB14, MDDGC14 |
| Background: | This gene is thought to encode a GDP-mannose pyrophosphorylase. The encoded protein catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, a reaction involved in the production of N-linked oligosaccharides. Alternatively spliced transcript variants encoding distinct isoforms have been described. |
| UniProt Protein Function: | GMPPB: This gene is thought to encode a GDP-mannose pyrophosphorylase. The encoded protein catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, a reaction involved in the production of N-linked oligosaccharides. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2009] |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 2.7.7.13; Carbohydrate Metabolism - fructose and mannose; Transferase Chromosomal Location of Human Ortholog: 3p21.31 Cellular Component: cytoplasm Molecular Function:protein binding Disease: Muscular Dystrophy-dystroglycanopathy (congenital With Brain And Eye Anomalies), Type A, 14; Muscular Dystrophy-dystroglycanopathy (congenital With Mental Retardation), Type B, 14; Muscular Dystrophy-dystroglycanopathy (limb-girdle), Type C, 14 |
| NCBI Summary: | This gene is thought to encode a GDP-mannose pyrophosphorylase. The encoded protein catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, a reaction involved in the production of N-linked oligosaccharides. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2009] |
| UniProt Code: | Q9Y5P6 |
| NCBI GenInfo Identifier: | 160013885 |
| NCBI Gene ID: | 29925 |
| NCBI Accession: | Q9Y5P6.2 |
| UniProt Secondary Accession: | Q9Y5P6,Q9H7U3, A8K6N5, |
| UniProt Related Accession: | Q9Y5P6 |
| Molecular Weight: | 42,622 Da |
| NCBI Full Name: | Mannose-1-phosphate guanyltransferase beta |
| NCBI Synonym Full Names: | GDP-mannose pyrophosphorylase B |
| NCBI Official Symbol: | GMPPB |
| NCBI Official Synonym Symbols: | MDDGA14; MDDGB14; MDDGC14 |
| NCBI Protein Information: | mannose-1-phosphate guanyltransferase beta |
| UniProt Protein Name: | Mannose-1-phosphate guanyltransferase beta |
| UniProt Synonym Protein Names: | GDP-mannose pyrophosphorylase B; GTP-mannose-1-phosphate guanylyltransferase beta |
| Protein Family: | Mannose-1-phosphate guanyltransferase |
| UniProt Gene Name: | GMPPB |
| UniProt Entry Name: | GMPPB_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GMPPB antibody (CAB16520) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s. |
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