Cell Biology Antibodies 5
Anti-GMDS Antibody (CAB15060)
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- SKU:
- CAB15060
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GMDS Antibody |
| Antibody SKU: | CAB15060 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GMDS (NP_001491.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HeLa |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GMDS (NP_001491.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAHA PARC PSAR GSGD GEMG KPRN VALI TGIT GQDG SYLA EFLL EKGY EVHG IVRR SSSF NTGR IEHL YKNP QAHI EGNM KLHY GDLT DSTC LVKI INEV |
| Gene ID: | 2762 |
| Uniprot: | O60547 |
| Cellular Location: | |
| Calculated MW: | 39kDa/41kDa |
| Observed MW: | 42kDa |
| Synonyms: | GMDS, GMD, SDR3E1, GDP-mannose 4 |
| Background: |
| UniProt Protein Function: | GMD: an enzyme that converts GDP-D-mannose to GDP-4-keto-6-D- deoxymannose. Perticipates in the extravasation of activated lymphocytes. |
| UniProt Protein Details: | Protein type:Lyase; Carbohydrate Metabolism - fructose and mannose; EC 4.2.1.47; Carbohydrate Metabolism - amino sugar and nucleotide sugar Chromosomal Location of Human Ortholog: 6p25 Cellular Component: cytoplasm Molecular Function:GDP-mannose 4,6-dehydratase activity Biological Process: Notch signaling pathway; GDP-mannose metabolic process; 'de novo' GDP-L-fucose biosynthetic process |
| NCBI Summary: | GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009] |
| UniProt Code: | O60547 |
| NCBI GenInfo Identifier: | 9087147 |
| NCBI Gene ID: | 2762 |
| NCBI Accession: | O60547.1 |
| UniProt Secondary Accession: | O60547,O75357, Q5T954, Q6FH09, Q9UGZ3, Q9UJK9, E9PI88 |
| UniProt Related Accession: | O60547 |
| Molecular Weight: | 372 |
| NCBI Full Name: | GDP-mannose 4,6 dehydratase |
| NCBI Synonym Full Names: | GDP-mannose 4,6-dehydratase |
| NCBI Official Symbol: | GMDS |
| NCBI Official Synonym Symbols: | GMD; SDR3E1 |
| NCBI Protein Information: | GDP-mannose 4,6 dehydratase; GDP-D-mannose dehydratase; short chain dehydrogenase/reductase family 3E, member 1 |
| UniProt Protein Name: | GDP-mannose 4,6 dehydratase |
| UniProt Synonym Protein Names: | GDP-D-mannose dehydratase; GMD |
| Protein Family: | GDP-mannose 4,6 dehydratase |
| UniProt Gene Name: | GMDS |
| UniProt Entry Name: | GMDS_HUMAN |
 | Western blot analysis of extracts of HeLa cells, using GMDS antibody (CAB15060) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60. |
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