Cell Biology Antibodies 12

Anti-GLYR1 Antibody (CAB9046)

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SKU:
CAB9046
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GLYR1 Antibody
Antibody SKU:CAB9046
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 70-270 of human GLYR1 (NP_115958.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:100 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, Mouse brain, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 70-270 of human GLYR1 (NP_115958.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MIKI NKGK RFQQ AVDA VEEF LRRA KGKD QTSS HNSS DDKN RRNS SEER SRPN SGDE KRKL SLSE GKVK KNMG EGKK RVSS GSSE RGSK SPLK RAQE QSPR KRGR PPKD EKDL TIPE SSTV KGMM AGPM AAFK WQPT ASEP VKDA DPHF HHFL LSQT EKPA VCYQ AITK KLKI CEEE TGST SIQA ADST AVNG SITP TDKK I
Gene ID:84656
Uniprot:Q49A26
Cellular Location:Nucleus
Calculated MW:51kDa/52kDa/58kDa/59kDa/60kDa
Observed MW:60kDa
Synonyms:GLYR1, BM045, HIBDL, N-PAC, NP60
Background:
UniProt Protein Function:Putative oxidoreductase that is recruited on chromatin and promotes KDM1B demethylase activity (PubMed:23260659). Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3) (PubMed:20850016). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664).
UniProt Code:Q49A26
NCBI GenInfo Identifier:862669336
NCBI Gene ID:84656
NCBI Accession:NP_001295025.1
UniProt Secondary Accession:Q49A26,Q5U632, Q6P1Q2, Q6V3W7, Q9BTI1, Q9BXK2, B4DL47 C9JJ40, C9JJ60,
UniProt Related Accession:Q49A26
Molecular Weight:52,559 Da
NCBI Full Name:putative oxidoreductase GLYR1 isoform 2
NCBI Synonym Full Names:glyoxylate reductase 1 homolog
NCBI Official Symbol:GLYR1  
NCBI Official Synonym Symbols:NP60; BM045; HIBDL; N-PAC  
NCBI Protein Information:putative oxidoreductase GLYR1
UniProt Protein Name:Putative oxidoreductase GLYR1
UniProt Synonym Protein Names:3-hydroxyisobutyrate dehydrogenase-like protein; Cytokine-like nuclear factor N-PAC; Glyoxylate reductase 1 homolog; Nuclear protein NP60; Nuclear protein of 60 kDa
UniProt Gene Name:GLYR1  
Anti-GLYR1 Polyclonal Antibody (CAB9046)Western blot analysis of extracts of various cell lines, using GLYR1 antibody (CAB9046) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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