Metabolism Antibodies 3
Anti-Glutathione Synthetase Antibody (CAB11557)
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- SKU:
- CAB11557
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-Glutathione Synthetase Antibody |
| Antibody SKU: | CAB11557 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Glutathione Synthetase |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, 293T, HepG2, Mouse lung, Mouse liver, Mouse kidney, Rat lung, Rat liver, Rat kidney |
| Immunogen: | A synthesized peptide derived from human Glutathione Synthetase |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2937 |
| Uniprot: | P48637 |
| Cellular Location: | |
| Calculated MW: | 52kDa |
| Observed MW: | 52KDa |
 | Western blot - Glutathione Synthetase Rabbit mAb (CAB11557) |
| Synonyms: | GSHS, HEL-S-64p, HEL-S-88n |
| Background: | Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | GSS: Defects in GSS are the cause of glutathione synthetase deficiency (GSS deficiency); also known as 5- oxoprolinuria or pyroglutamic aciduria. It is a severe form characterized by an increased rate of hemolysis and defective function of the central nervous system. Defects in GSS are the cause of glutathione synthetase deficiency of erythrocytes (GLUSYNDE)[MIM:231900]. Glutathione synthetase deficiency of erythrocytes is a mild form causing hemolytic anemia. Belongs to the eukaryotic GSH synthase family. |
| UniProt Protein Details: | Protein type:EC 6.3.2.3; Other Amino Acids Metabolism - glutathione; Ligase Chromosomal Location of Human Ortholog: 20q11.2 Cellular Component: cytosol Molecular Function:protein homodimerization activity; glutathione binding; glycine binding; magnesium ion binding; glutathione synthase activity; ATP binding Biological Process: amino acid metabolic process; response to nutrient levels; nervous system development; response to cadmium ion; xenobiotic metabolic process; glutathione biosynthetic process; response to oxidative stress; response to amino acid stimulus; aging Disease: Glutathione Synthetase Deficiency; Glutathione Synthetase Deficiency Of Erythrocytes, Hemolytic Anemia Due To |
| NCBI Summary: | Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P48637 |
| NCBI GenInfo Identifier: | 1346191 |
| NCBI Gene ID: | 2937 |
| NCBI Accession: | P48637.1 |
| UniProt Secondary Accession: | P48637,Q4TTD9, B2R697, B6F210, E1P5P9, |
| UniProt Related Accession: | P48637 |
| Molecular Weight: | 474 |
| NCBI Full Name: | Glutathione synthetase |
| NCBI Synonym Full Names: | glutathione synthetase |
| NCBI Official Symbol: | GSS |
| NCBI Official Synonym Symbols: | GSHS; HEL-S-64p; HEL-S-88n |
| NCBI Protein Information: | glutathione synthetase; GSH-S; GSH synthetase; glutathione synthase; epididymis secretory sperm binding protein Li 64p; epididymis secretory sperm binding protein Li 88n |
| UniProt Protein Name: | Glutathione synthetase |
| UniProt Synonym Protein Names: | Glutathione synthase |
| Protein Family: | Glutathione synthetase |
| UniProt Gene Name: | GSS |
| UniProt Entry Name: | GSHB_HUMAN |
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