Cell Biology Antibodies 16
Anti-Glutaminase Antibody (CAB11043)
- SKU:
- CAB11043
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-Glutaminase Antibody |
Antibody SKU: | CAB11043 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IF |
Reactivity: | Human |
Host Species: | Rabbit |
Immunogen: | A synthesized peptide derived from human Glutaminase |
Application: | WB IF |
Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
Reactivity: | Human |
Positive Samples: | 293T, HepG2, SH-SY5Y |
Immunogen: | A synthesized peptide derived from human Glutaminase |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 2744 |
Uniprot: | O94925 |
Cellular Location: | |
Calculated MW: | 65, 73kDa |
Observed MW: | 55-65KDa |
Synonyms: | AAD20, GAC, GAM, GLS1, KGA |
Background: | This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] |
UniProt Protein Function: | glutaminase: Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity. Belongs to the glutaminase family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Amino Acid Metabolism - arginine and proline; Hydrolase; Mitochondrial; Amino Acid Metabolism - alanine, aspartate and glutamate; Other Amino Acids Metabolism - D-Glutamine and D-glutamate; Energy Metabolism - nitrogen; EC 3.5.1.2 Chromosomal Location of Human Ortholog: 2q32-q34 Cellular Component: mitochondrion; mitochondrial matrix; cytosol Molecular Function:protein binding; glutaminase activity Biological Process: synaptic transmission; glutamate secretion; suckling behavior; neurotransmitter secretion; glutamine catabolic process; neurological control of breathing; glutamate biosynthetic process; amino acid biosynthetic process; protein homotetramerization |
NCBI Summary: | This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] |
UniProt Code: | O94925 |
NCBI GenInfo Identifier: | 12643334 |
NCBI Gene ID: | 2744 |
NCBI Accession: | O94925.1 |
UniProt Related Accession: | O94925 |
Molecular Weight: | 65; 73kDa |
NCBI Full Name: | Glutaminase kidney isoform, mitochondrial |
NCBI Synonym Full Names: | glutaminase |
NCBI Official Symbol: | GLS |
NCBI Official Synonym Symbols: | GAC; GAM; KGA; GLS1; AAD20; GDPAG; CASGID; EIEE71 |
NCBI Protein Information: | glutaminase kidney isoform, mitochondrial |
UniProt Protein Name: | Glutaminase kidney isoform, mitochondrial |
UniProt Synonym Protein Names: | K-glutaminase; L-glutamine amidohydrolase |
Protein Family: | Glutaminase |
UniProt Gene Name: | GLS |
UniProt Entry Name: | GLSK_HUMAN |