Signal Transduction Antibodies 3
Anti-GLUT2 Antibody (CAB12307)
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- SKU:
- CAB12307
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-GLUT2 Antibody |
| Antibody SKU: | CAB12307 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human GLUT2 |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-29, K-562, Rat liver, Rat kidney |
| Immunogen: | A synthesized peptide derived from human GLUT2 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6514 |
| Uniprot: | P11168 |
| Cellular Location: | |
| Calculated MW: | 57kDa |
| Observed MW: | 57KDa |
 | Western blot - GLUT2 Rabbit mAb (CAB12307) |
| Synonyms: | GLUT2 |
| Background: | This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] |
| UniProt Protein Function: | GLUT2: an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. Present at high levels in the plasma membrane of pancreatic b-cells where it initiates the first step in glucose-stimulated insulin secretion, a glucose metabolism-dependent signaling mechanism. May mediate the bidirectional transfer of glucose across the plasma membrane of hepatocytes. May also participate with the Na( +2)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Required for glucose sensitivity in the hypothalamus and brain stem. Involved in the control of food intake and stimulation of glucose uptake by peripheral tissues. |
| UniProt Protein Details: | Protein type:Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 3q26.1-q26.2 Cellular Component: membrane; integral to plasma membrane; cytoplasm; plasma membrane; brush border Molecular Function:D-glucose transmembrane transporter activity; dehydroascorbic acid transporter activity; glucose transmembrane transporter activity; hexose transmembrane transporter activity Biological Process: hexose transport; carbohydrate metabolic process; energy reserve metabolic process; pathogenesis; glucose transport; endocrine pancreas development; transmembrane transport; regulation of insulin secretion Disease: Fanconi-bickel Syndrome; Diabetes Mellitus, Noninsulin-dependent |
| NCBI Summary: | This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] |
| UniProt Code: | P11168 |
| NCBI GenInfo Identifier: | 121756 |
| NCBI Gene ID: | 6514 |
| NCBI Accession: | P11168.1 |
| UniProt Secondary Accession: | P11168,Q9UCW9, A8K481, B2R936, B7Z547, F8W8V8, |
| UniProt Related Accession: | P11168 |
| Molecular Weight: | 44,702 Da |
| NCBI Full Name: | Solute carrier family 2, facilitated glucose transporter member 2 |
| NCBI Synonym Full Names: | solute carrier family 2 (facilitated glucose transporter), member 2 |
| NCBI Official Symbol: | SLC2A2 |
| NCBI Official Synonym Symbols: | GLUT2 |
| NCBI Protein Information: | solute carrier family 2, facilitated glucose transporter member 2; glucose transporter type 2, liver |
| UniProt Protein Name: | Solute carrier family 2, facilitated glucose transporter member 2 |
| UniProt Synonym Protein Names: | Glucose transporter type 2, liver; GLUT-2 |
| Protein Family: | Solute carrier family |
| UniProt Gene Name: | SLC2A2 |
| UniProt Entry Name: | GTR2_HUMAN |
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