Cell Biology Antibodies 17
Anti-GLUD1 Antibody (CAB5176)
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- SKU:
- CAB5176
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GLUD1 Antibody |
| Antibody SKU: | CAB5176 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human GLUD1 |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat, K-562, U-252MGMouse liver, Rat liver |
| Immunogen: | A synthesized peptide derived from human GLUD1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2746 |
| Uniprot: | P00367 |
| Cellular Location: | |
| Calculated MW: | 50kDa |
| Observed MW: | 52KDa |
| Synonyms: | GDH, GDH1, GLUD |
| Background: | This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X. [provided by RefSeq, Jan 2016] |
| UniProt Protein Function: | Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. |
| NCBI Summary: | This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X. [provided by RefSeq, Jan 2016] |
| UniProt Code: | P00367 |
| NCBI GenInfo Identifier: | 974141156 |
| NCBI Gene ID: | 2746 |
| NCBI Accession: | NP_001305829.1 |
| UniProt Secondary Accession: | P00367,Q5TBU3, B3KV55, B4DGN5, |
| UniProt Related Accession: | P00367 |
| Molecular Weight: | 46,575 Da |
| NCBI Full Name: | glutamate dehydrogenase 1, mitochondrial isoform b |
| NCBI Synonym Full Names: | glutamate dehydrogenase 1 |
| NCBI Official Symbol: | GLUD1 |
| NCBI Official Synonym Symbols: | GDH; GDH1; GLUD |
| NCBI Protein Information: | glutamate dehydrogenase 1, mitochondrial |
| UniProt Protein Name: | Glutamate dehydrogenase 1, mitochondrial |
| UniProt Gene Name: | GLUD1 |
 | Western blot - GLUD1 Rabbit mAb (CAB5176) |
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