Signal Transduction Antibodies 3

Anti-GluA4 Antibody (CAB4593)

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SKU:
CAB4593
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-GluA4 Antibody
Antibody SKU:CAB4593
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human GluA4
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:A synthesized peptide derived from human GluA4
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2893
Uniprot:P48058
Cellular Location:
Calculated MW:101kDa
Observed MW:101KDa
Synonyms:GLUR4, GLUR4C, GLURD, GluA4
Background:Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]
UniProt Protein Function:GluR4: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA(quisqualate) > glutamate > kainate. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q22

Cellular Component: cell junction; cell soma; dendrite; plasma membrane; postsynaptic membrane; terminal button

Molecular Function:alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity

Biological Process: glutamate signaling pathway; ionotropic glutamate receptor signaling pathway; synaptic transmission; transport

NCBI Summary:Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]
UniProt Code:P48058
NCBI GenInfo Identifier:218512059
NCBI Gene ID:2893
NCBI Accession:P48058.2
UniProt Secondary Accession:P48058,Q86XE8,
UniProt Related Accession:P48058
Molecular Weight:49,146 Da
NCBI Full Name:Glutamate receptor 4
NCBI Synonym Full Names:glutamate ionotropic receptor AMPA type subunit 4
NCBI Official Symbol:GRIA4  
NCBI Official Synonym Symbols:GLUR4; GLURD; GluA4; GLUR4C  
NCBI Protein Information:glutamate receptor 4
UniProt Protein Name:Glutamate receptor 4
UniProt Synonym Protein Names:AMPA-selective glutamate receptor 4; GluR-D; Glutamate receptor ionotropic, AMPA 4; GluA4
Protein Family:Glutamate receptor
UniProt Gene Name:GRIA4  
UniProt Entry Name:GRIA4_HUMAN
Anti-GluA4 Antibody (CAB4593)Western blot - GluA4 Rabbit mAb (CAB4593)
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