Cell Biology Antibodies 9
Anti-GLRX Antibody (CAB5315)
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- SKU:
- CAB5315
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GLRX Antibody |
| Antibody SKU: | CAB5315 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-106 of human GLRX (NP_001112362.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW480, NCI-H460 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-106 of human GLRX (NP_001112362.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAQE FVNC KIQP GKVV VFIK PTCP YCRR AQEI LSQL PIKQ GLLE FVDI TATN HTNE IQDY LQQL TGAR TVPR VFIG KDCI GGCS DLVS LQQS GELL TRLK QIGA LQ |
| Gene ID: | 2745 |
| Uniprot: | P35754 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 11kDa |
| Observed MW: | 12kDa |
| Synonyms: | GLRX, GRX, GRX1 |
| Background: | This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. |
| UniProt Protein Function: | GLRX1: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. Belongs to the glutaredoxin family. |
| UniProt Protein Details: | Protein type:Oxidoreductase Chromosomal Location of Human Ortholog: 5q14 Cellular Component: mitochondrion; nucleus; cytosol Molecular Function:electron carrier activity; protein N-terminus binding; glutathione disulfide oxidoreductase activity Biological Process: cell redox homeostasis; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; positive regulation of membrane potential |
| NCBI Summary: | This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011] |
| UniProt Code: | P35754 |
| NCBI GenInfo Identifier: | 1346143 |
| NCBI Gene ID: | 2745 |
| NCBI Accession: | P35754.2 |
| UniProt Secondary Accession: | P35754,Q3KQS1, Q6ICT1, B2R4L2, |
| UniProt Related Accession: | P35754 |
| Molecular Weight: | 106 |
| NCBI Full Name: | Glutaredoxin-1 |
| NCBI Synonym Full Names: | glutaredoxin (thioltransferase) |
| NCBI Official Symbol: | GLRX |
| NCBI Official Synonym Symbols: | GRX; GRX1 |
| NCBI Protein Information: | glutaredoxin-1; TTase-1; thioltransferase-1 |
| UniProt Protein Name: | Glutaredoxin-1 |
| UniProt Synonym Protein Names: | Thioltransferase-1; TTase-1 |
| UniProt Gene Name: | GLRX |
| UniProt Entry Name: | GLRX1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GLRX antibody (CAB5315) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded rat spleen using GLRX Antibody (CAB5315) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human kidney cancer using GLRX Antibody (CAB5315) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse spleen using GLRX Antibody (CAB5315) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of C6 cells using GLRX antibody (CAB5315) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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