Cell Biology Antibodies 10

Anti-GLP2R Antibody (CAB6602)

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SKU:
CAB6602
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GLP2R Antibody
Antibody SKU:CAB6602
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human GLP2R (NP_004237.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:NCI-H460, HeLa, HepG2, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human GLP2R (NP_004237.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MKLG SSRA GPGR GSAG LLPG VHEL PMGI PAPW GTSP LSFH RKCS LWAP GRPF LTLV LLVS IKQV TGSL LEET TRKW AQYK QACL RDLL KEPS GIFC NGTF DQYV CWPH SSPG NVSV PCPS YLPW WSEE SSGR AYRH CLAQ GTWQ TIEN ATDI WQDD SECS ENHS FKQN VDRY ALLS TLQL
Gene ID:9340
Uniprot:O95838
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:63kDa
Observed MW:63kDa
Synonyms:GLP2R
Background:This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis.
UniProt Protein Function:GLP2R: This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family.
UniProt Protein Details:

Protein type:Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 2; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: plasma membrane; integral to membrane

Molecular Function:G-protein coupled receptor activity; glucagon receptor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; positive regulation of cell proliferation

NCBI Summary:This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. [provided by RefSeq, Dec 2014]
UniProt Code:O95838
NCBI GenInfo Identifier:12230071
NCBI Gene ID:9340
NCBI Accession:O95838.1
UniProt Secondary Accession:O95838,Q4VAT3,
UniProt Related Accession:O95838
Molecular Weight:Calculated: 63kDaObserved: 63kDa
NCBI Full Name:Glucagon-like peptide 2 receptor
NCBI Synonym Full Names:glucagon-like peptide 2 receptor
NCBI Official Symbol:GLP2R  
NCBI Protein Information:glucagon-like peptide 2 receptor; GLP-2 receptor
UniProt Protein Name:Glucagon-like peptide 2 receptor
Protein Family:Glucagon-like peptide 2 receptor
UniProt Gene Name:GLP2R  
UniProt Entry Name:GLP2R_HUMAN
Anti-GLP2R Antibody (CAB6602)Western blot analysis of extracts of various cell lines, using GLP2R antibody (CAB6602) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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