Cell Biology Antibodies 4
Anti-GLP1R Antibody (CAB13990)
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- SKU:
- CAB13990
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GLP1R Antibody |
| Antibody SKU: | CAB13990 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-116 of human GLP1R (NP_002053.3). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Rat |
| Positive Samples: | U-87MG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-116 of human GLP1R (NP_002053.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GPRP QGAT VSLW ETVQ KWRE YRRQ CQRS LTED PPPA TDLF CNRT FDEY ACWP DGEP GSFV NVSC PWYL PWAS SVPQ GHVY RFCT AEGL WLQK DNS |
| Gene ID: | 2740 |
| Uniprot: | P43220 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 53kDa |
| Observed MW: | 53kDa |
| Synonyms: | GLP1R, GLP-1, GLP-1-R, GLP-1R |
| Background: | This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. |
| UniProt Protein Function: | GLP1R: This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 2 Chromosomal Location of Human Ortholog: 6p21 Cellular Component: cytosol; integral to membrane; intracellular; plasma membrane Molecular Function:glucagon receptor activity; protein binding; transmembrane receptor activity Biological Process: adenylate cyclase activation; cAMP-mediated signaling; cell surface receptor linked signal transduction; elevation of cytosolic calcium ion concentration; energy reserve metabolic process; G-protein coupled receptor protein signaling pathway; learning and/or memory; positive regulation of blood pressure; regulation of heart contraction; regulation of insulin secretion; response to stress |
| NCBI Summary: | This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016] |
| UniProt Code: | P43220 |
| NCBI GenInfo Identifier: | 311033387 |
| NCBI Gene ID: | 2740 |
| NCBI Accession: | P43220.2 |
| UniProt Secondary Accession: | P43220,Q2M229, Q99669, |
| UniProt Related Accession: | P43220 |
| Molecular Weight: | |
| NCBI Full Name: | Glucagon-like peptide 1 receptor |
| NCBI Synonym Full Names: | glucagon like peptide 1 receptor |
| NCBI Official Symbol: | GLP1R |
| NCBI Official Synonym Symbols: | GLP-1; GLP-1R; GLP-1-R |
| NCBI Protein Information: | glucagon-like peptide 1 receptor |
| UniProt Protein Name: | Glucagon-like peptide 1 receptor |
| Protein Family: | Glucagon-like peptide 1 receptor |
| UniProt Gene Name: | GLP1R |
| UniProt Entry Name: | GLP1R_HUMAN |
 | Western blot analysis of extracts of U-87MG cells, using GLP1R antibody (CAB13990) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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