Cell Biology Antibodies 17

Anti-GLO1 Antibody (CAB4329)

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SKU:
CAB4329
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GLO1 Antibody
Antibody SKU:CAB4329
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human GLO1
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, Mouse brain, Mouse kidney, Rat lung, Rat brain
Immunogen:A synthesized peptide derived from human GLO1
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2739
Uniprot:Q04760
Cellular Location:
Calculated MW:21kDa
Observed MW:22KDa
Synonyms:GLOD1, GLYI, HEL-S-74
Background:The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008]
UniProt Protein Function:GLO1: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF- kappa-B. Belongs to the glyoxalase I family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Carbohydrate Metabolism - pyruvate; EC 4.4.1.5; Lyase

Chromosomal Location of Human Ortholog: 6p21.3-p21.1

Cellular Component: cytoplasm

Molecular Function:zinc ion binding; lactoylglutathione lyase activity

Biological Process: regulation of transcription from RNA polymerase II promoter; glutathione metabolic process; carbohydrate metabolic process; osteoclast differentiation; methylglyoxal metabolic process; negative regulation of apoptosis

Disease: Autism

NCBI Summary:The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008]
UniProt Code:Q04760
NCBI GenInfo Identifier:134039205
NCBI Gene ID:2739
NCBI Accession:Q04760.4
UniProt Secondary Accession:Q04760,P78375, Q59EL0, Q5TZW3, Q96FC0, Q96J41, B2R6P7 B4DDV0,
UniProt Related Accession:Q04760
Molecular Weight:Calculated: 19kDa/20kDaObserved: 21kDa
NCBI Full Name:Lactoylglutathione lyase
NCBI Synonym Full Names:glyoxalase I
NCBI Official Symbol:GLO1  
NCBI Official Synonym Symbols:GLYI; GLOD1; HEL-S-74  
NCBI Protein Information:lactoylglutathione lyase; glx I; aldoketomutase; methylglyoxalase; ketone-aldehyde mutase; lactoyl glutathione lyase; glyoxalase domain containing 1; epididymis secretory protein Li 74; S-D-lactoylglutathione methylglyoxal lyase
UniProt Protein Name:Lactoylglutathione lyase
UniProt Synonym Protein Names:Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase
UniProt Gene Name:GLO1  
UniProt Entry Name:LGUL_HUMAN
Anti-GLO1 Antibody (CAB4329)Western blot - GLO1 Rabbit mAb (CAB4329)
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