Cell Death Antibodies 1
Anti-GLIPR1 Antibody (CAB16490)
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- SKU:
- CAB16490
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-GLIPR1 Antibody |
| Antibody SKU: | CAB16490 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-140 of human GLIPR1 (NP_006842.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: | Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-140 of human GLIPR1 (NP_006842.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ANIL PDIE NEDF IKDC VRIH NKFR SEVK PTAS DMLY MTWD PALA QIAK AWAS NCQF SHNT RLKP PHKL HPNF TSLG ENIW TGSV PIFS VSSA ITNW YDEI QDYD FKTR ICKK VCGH YTQ |
| Gene ID: | 11010 |
| Uniprot: | P48060 |
| Cellular Location: | Membrane, Single-pass membrane protein |
| Calculated MW: | 26kDa/30kDa |
| Observed MW: | 28kDa |
| Synonyms: | GLIPR1, CRISP7, GLIPR, RTVP1 |
| Background: | This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. |
| UniProt Protein Function: | GLIPR1: a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 12q21.2 Cellular Component: membrane; plasma membrane Biological Process: neutrophil degranulation; regulation of lipid metabolic process |
| NCBI Summary: | This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P48060 |
| NCBI GenInfo Identifier: | 110825980 |
| NCBI Gene ID: | 11010 |
| NCBI Accession: | NP_006842.2 |
| UniProt Secondary Accession: | P48060,Q15409, Q969K2, A7YET6, F8VUC2, |
| UniProt Related Accession: | P48060 |
| Molecular Weight: | 28.2kD |
| NCBI Full Name: | glioma pathogenesis-related protein 1 |
| NCBI Synonym Full Names: | GLI pathogenesis related 1 |
| NCBI Official Symbol: | GLIPR1 |
| NCBI Official Synonym Symbols: | GLIPR; RTVP1; CRISP7 |
| NCBI Protein Information: | glioma pathogenesis-related protein 1 |
| UniProt Protein Name: | Glioma pathogenesis-related protein 1 |
| UniProt Synonym Protein Names: | Protein RTVP-1 |
| Protein Family: | GDSL esterase/lipase |
| UniProt Gene Name: | GLIPR1 |
 | Western blot analysis of extracts of rat lung, using GLIPR1 antibody (CAB16490) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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