Cell Biology Antibodies 8

Anti-GJD2 Antibody (CAB2883)

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SKU:
CAB2883
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GJD2 Antibody
Antibody SKU:CAB2883
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 99-197 of human GJD2 (NP_065711.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HL-60, Jurkat, SH-SY5Y, Mouse pancreas, Mouse eye, Mouse brain, Rat pancreas, Rat eye, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 99-197 of human GJD2 (NP_065711.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:HQSA KQRE RRYS TVFL ALDR DPPE SIGG PGGT GGGG SGGG KRED KKLQ NAIV NGVL QNTE NTSK ETEP DCLE VKEL TPHP SGLR TASK SKLR RQEG ISR
Gene ID:57369
Uniprot:Q9UKL4
Cellular Location:Cell junction, Cell membrane, Multi-pass membrane protein, gap junction
Calculated MW:36kDa
Observed MW:37kDa
Synonyms:GJD2, CX36, GJA9
Background:This gene encodes a member of the connexin protein family. Connexins are gap junction proteins which are arranged in groups of 6 around a central pore to form a connexon, a component of the gap junction intercellular channel. The channels formed by this protein allow cationic molecule exchange between human beta cells and may function in the regulation of insulin secretion.
UniProt Protein Function:GJD2: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. Delta-type subfamily.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Cell adhesion; Membrane protein, integral; Channel, misc.

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: connexon complex; plasma membrane; integral to membrane

Molecular Function:gap junction channel activity

Biological Process: synaptic transmission; regulation of action potential; visual perception; transmembrane transport

NCBI Summary:This gene encodes a member of the connexin protein family. Connexins are gap junction proteins which are arranged in groups of 6 around a central pore to form a connexon, a component of the gap junction intercellular channel. The channels formed by this protein allow cationic molecule exchange between human beta cells and may function in the regulation of insulin secretion. [provided by RefSeq, Oct 2012]
UniProt Code:Q9UKL4
NCBI GenInfo Identifier:8928073
NCBI Gene ID:57369
NCBI Accession:Q9UKL4.1
UniProt Secondary Accession:Q9UKL4,O70610, O54851, Q866T7,
UniProt Related Accession:Q9UKL4
Molecular Weight:321
NCBI Full Name:Gap junction delta-2 protein
NCBI Synonym Full Names:gap junction protein, delta 2, 36kDa
NCBI Official Symbol:GJD2  
NCBI Official Synonym Symbols:CX36; GJA9  
NCBI Protein Information:gap junction delta-2 protein; connexin 36; connexin-36; gap junction alpha-9 protein
UniProt Protein Name:Gap junction delta-2 protein
UniProt Synonym Protein Names:Connexin-36; Cx36; Gap junction alpha-9 protein
UniProt Gene Name:GJD2  
UniProt Entry Name:CXD2_HUMAN
Anti-GJD2 Antibody (CAB2883)Western blot analysis of extracts of various cell lines, using GJD2 antibody (CAB2883) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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