Cell Biology Antibodies 12

Anti-GJB4 Antibody (CAB9888)

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SKU:
CAB9888
Product Type:
Antibody
Applications:
WB
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GJB4 Antibody
Antibody SKU:CAB9888
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 100-200 of human GJB4 (NP_694944.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse liver, Rat skin
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 100-200 of human GJB4 (NP_694944.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ERER KHHL KHGP NAPS LYDN LSKK RGGL WWTY LLSL IFKA AVDA GFLY IFHR LYKD YDMP RVVA CSVE PCPH TVDC YISR PTEK KVFT YFMV TTAA ICIL L
Gene ID:127534
Uniprot:Q9NTQ9
Cellular Location:Cell junction, Cell membrane, Multi-pass membrane protein, gap junction
Calculated MW:30kDa
Observed MW:30kDa
Synonyms:GJB4, CX30.3, EKV, EKVP2
Background:This gene encodes a transmembrane connexin protein that is a component of gap junctions. Mutations in this gene have been associated with erythrokeratodermia variabilis, progressive symmetric erythrokeratoderma and hearing impairment.
UniProt Protein Function:GJB4: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Defects in GJB4 are a cause of erythrokeratodermia variabilis (EKV). EKV is a genodermatosis characterized by the appearance of two independent skin lesions: transient figurate erythematous patches and hyperkeratosis that is usually localized but occasionally occurs in its generalized form. Clinical presentation varies significantly within a family and from one family to another. Palmoplantar keratoderma is present in around 50% of cases. Belongs to the connexin family. Beta-type (group I) subfamily.
UniProt Protein Details:

Protein type:Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: cell junction; nucleolus; nucleus

Disease: Erythrokeratodermia Variabilis Et Progressiva

NCBI Summary:This gene encodes a transmembrane connexin protein that is a component of gap junctions. Mutations in this gene have been associated with erythrokeratodermia variabilis, progressive symmetric erythrokeratoderma and hearing impairment. [provided by RefSeq, Dec 2009]
UniProt Code:Q9NTQ9
NCBI GenInfo Identifier:12229761
NCBI Gene ID:127534
NCBI Accession:Q9NTQ9.1
UniProt Secondary Accession:Q9NTQ9,B3KQ82,
UniProt Related Accession:Q9NTQ9
Molecular Weight:30kDa
NCBI Full Name:Gap junction beta-4 protein
NCBI Synonym Full Names:gap junction protein beta 4
NCBI Official Symbol:GJB4  
NCBI Official Synonym Symbols:EKV; CX30.3  
NCBI Protein Information:gap junction beta-4 protein
UniProt Protein Name:Gap junction beta-4 protein
UniProt Synonym Protein Names:Connexin-30.3; Cx30.3
Protein Family:Gap junction beta-4 protein
UniProt Gene Name:GJB4  
Anti-GJB4 Polyclonal Antibody (CAB9888)Western blot analysis of extracts of various cell lines, using GJB4 Antibody (CAB9888) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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