Cell Biology Antibodies 11
Anti-GJA5 Antibody (CAB7231)
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- SKU:
- CAB7231
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GJA5 Antibody |
| Antibody SKU: | CAB7231 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 229-358 of human GJA5 (NP_859054.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, Mouse heart, Rat heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 229-358 of human GJA5 (NP_859054.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LGWK KIRQ RFVK PRQH MAKC QLSG PSVG IVQS CTPP PDFN QCLE NGPG GKFF NPFS NNMA SQQN TDNL VTEQ VRGQ EQTP GEGF IQVR YGQK PEVP NGVS PGHR LPHG YHSD KRRL SKAS SKAR SDDL SV |
| Gene ID: | 2702 |
| Uniprot: | P36382 |
| Cellular Location: | Cell junction, Cell membrane, Multi-pass membrane protein, gap junction |
| Calculated MW: | 40kDa |
| Observed MW: | 40kDa |
| Synonyms: | GJA5, ATFB11, CX40 |
| Background: | This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript variants encoding the same isoform have been described. |
| UniProt Protein Function: | GJA5: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Defects in GJA5 are a cause of familial atrial standstill (FAS). Atrial standstill is an extremely rare arrhythmia, characterized by the absence of electrical and mechanical activity in the atria. Electrocardiographically, it is characterized by bradycardia, the absence of P waves, and a junctional narrow complex escape rhythm. Defects in GJA5 are the cause of familial atrial fibrillation type 11 (ATFB11). ATFB11 is a familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the connexin family. Alpha-type (group II) subfamily. |
| UniProt Protein Details: | Protein type:Channel, misc.; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q21.1 Cellular Component: connexon complex; cell projection; integral to plasma membrane; gap junction Molecular Function:gap junction hemi-channel activity Biological Process: gap junction assembly; negative regulation of glomerular filtration; positive regulation of vasodilation; protein oligomerization; positive regulation of vasoconstriction; artery morphogenesis; embryonic heart tube development; negative regulation of blood pressure; angiogenesis; skeletal development; transmembrane transport; potassium ion transport; embryonic limb morphogenesis Disease: Atrial Standstill 1; Atrial Fibrillation, Familial, 11 |
| NCBI Summary: | This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript variants encoding the same isoform have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P36382 |
| NCBI GenInfo Identifier: | 8928556 |
| NCBI Gene ID: | 2702 |
| NCBI Accession: | P36382.3 |
| UniProt Secondary Accession: | P36382,Q5T3B6, Q5U0N6, |
| UniProt Related Accession: | P36382 |
| Molecular Weight: | 40,380 Da |
| NCBI Full Name: | Gap junction alpha-5 protein |
| NCBI Synonym Full Names: | gap junction protein, alpha 5, 40kDa |
| NCBI Official Symbol: | GJA5 |
| NCBI Official Synonym Symbols: | CX40; ATFB11 |
| NCBI Protein Information: | gap junction alpha-5 protein; connexin 40; gap junction protein alpha 5 40kDa |
| UniProt Protein Name: | Gap junction alpha-5 protein |
| UniProt Synonym Protein Names: | Connexin-40; Cx40 |
| Protein Family: | Gap junction alpha-5 protein |
| UniProt Gene Name: | GJA5 |
| UniProt Entry Name: | CXA5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GJA5 antibody (CAB7231) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 60s. |
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