Cell Biology Antibodies 8

Anti-GJA4 Antibody (CAB2529)

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SKU:
CAB2529
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GJA4 Antibody
Antibody SKU:CAB2529
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 229-333 of human GJA4 (NP_002051.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:SW620, BT-474, 293T, NCI-H460
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 229-333 of human GJA4 (NP_002051.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VHLL CRCL SRGM RARQ GQDA PPTQ GTSS DPYT DQVF FYLP VGQG PSSP PCPT YNGL SSSE QNWA NLTT EERL ASSR PPLF LDPP PQNG QKPP SRPS SSAS KKQY V
Gene ID:2701
Uniprot:P35212
Cellular Location:Cell junction, Cell membrane, Multi-pass membrane protein, gap junction
Calculated MW:37kDa
Observed MW:43kDa
Synonyms:GJA4, CX37
Background:This gene encodes a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene have been associated with atherosclerosis and a higher risk of myocardial infarction.
UniProt Protein Function:GJA4: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. Alpha-type (group II) subfamily.
UniProt Protein Details:

Protein type:Membrane protein, integral; Cell adhesion; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p35.1

Cellular Component: connexon complex; integral to plasma membrane; gap junction

Molecular Function:protein binding

Biological Process: intercellular junction assembly; blood vessel development; cell-cell signaling; transport; calcium ion transport; response to pain

NCBI Summary:This gene encodes a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene have been associated with atherosclerosis and a higher risk of myocardial infarction. [provided by RefSeq, Jul 2008]
UniProt Code:P35212
NCBI GenInfo Identifier:8928555
NCBI Gene ID:2701
NCBI Accession:P35212.3
UniProt Secondary Accession:P35212,Q9P106, Q9UBL1, Q9UNA9, Q9UNB0, Q9UNB1, Q9Y5N7 A8K698, D3DPR4,
UniProt Related Accession:P35212
Molecular Weight:
NCBI Full Name:Gap junction alpha-4 protein
NCBI Synonym Full Names:gap junction protein, alpha 4, 37kDa
NCBI Official Symbol:GJA4  
NCBI Official Synonym Symbols:CX37  
NCBI Protein Information:gap junction alpha-4 protein; connexin 37; connexin-37
UniProt Protein Name:Gap junction alpha-4 protein
UniProt Synonym Protein Names:Connexin-37; Cx37
Protein Family:Gap junction alpha-4 protein
UniProt Gene Name:GJA4  
UniProt Entry Name:CXA4_HUMAN
Anti-GJA4 Antibody (CAB2529)Western blot analysis of extracts of various cell lines, using GJA4 antibody (CAB2529) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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