Name: Anti-GITR Ligand/TNFSF18 Antibody (CAB7028)
Brand: Immunology Antibodies 2
SKU: CAB7028
Availability: OutOfStock

Antibody Name:	Anti-GITR Ligand/TNFSF18 Antibody
Antibody SKU:	CAB7028
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 72-199 of human GITR Ligand/TNFSF18 (NP_005083.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	SW620, SKOV3, Mouse skeletal muscle, Rat skeletal muscle

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 72-199 of human GITR Ligand/TNFSF18 (NP_005083.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	QLET AKEP CMAK FGPL PSKW QMAS SEPP CVNK VSDW KLEI LQNG LYLI YGQV APNA NYND VAPF EVRL YKNK DMIQ TLTN KSKI QNVG GTYE LHVG DTID LIFN SEHQ VLKN NTYW GIIL LANP QFIS
Gene ID:	8995
Uniprot:	Q9UNG2
Cellular Location:	Cell membrane, Single-pass type II membrane protein
Calculated MW:	22kDa
Observed MW:	46kDa

Synonyms:

TNFSF18, AITRL, GITRL, TL6, TNLG2A, hGITRL

Background:

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.

UniProt Protein Function:	TNFSF18: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Belongs to the tumor necrosis factor family.
UniProt Protein Details:	Protein type:Apoptosis; Membrane protein, integral; Cytokine Chromosomal Location of Human Ortholog: 1q23 Cellular Component: extracellular space; cell surface; integral to membrane; plasma membrane Molecular Function:cytokine activity; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding; receptor binding Biological Process: cell-cell signaling; tumor necrosis factor-mediated signaling pathway; T cell proliferation during immune response; regulation of T cell proliferation; signal transduction; negative regulation of apoptosis; activation of NF-kappaB transcription factor
NCBI Summary:	The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9UNG2
NCBI GenInfo Identifier:	325511353
NCBI Gene ID:	8995
NCBI Accession:	Q9UNG2.2
UniProt Secondary Accession:	Q9UNG2,O95852, Q6ISV1, A9IQG8,
UniProt Related Accession:	Q9UNG2
Molecular Weight:	22,724 Da
NCBI Full Name:	Tumor necrosis factor ligand superfamily member 18
NCBI Synonym Full Names:	tumor necrosis factor (ligand) superfamily, member 18
NCBI Official Symbol:	TNFSF18
NCBI Official Synonym Symbols:	TL6; AITRL; GITRL; hGITRL
NCBI Protein Information:	tumor necrosis factor ligand superfamily member 18; AITR ligand; GITR ligand; activation-inducible TNF-related ligand; glucocorticoid-induced TNF-related ligand; glucocorticoid-induced TNFR-related protein ligand
UniProt Protein Name:	Tumor necrosis factor ligand superfamily member 18
UniProt Synonym Protein Names:	Activation-inducible TNF-related ligand; AITRL; Glucocorticoid-induced TNF-related ligand; hGITRL
UniProt Gene Name:	TNFSF18
UniProt Entry Name:	TNF18_HUMAN

Anti-GITR Ligand/TNFSF18 Antibody (CAB7028)

Western blot analysis of extracts of various cell lines, using GITR Ligand/TNFSF18 antibody (CAB7028) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

ELISA Kits

Human Tumor necrosis factor ligand superfamily member 18 (TNFSF18) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)