Description
system_update_altDatasheet
Product Code: | HDLA040 |
Size: | 100 µg |
Clonality: | Monoclonal |
Clone: | DM78 |
Synonyms: | AITR, GITR, TNFRSF18, CD357 |
Applications: | ELISA, Flow Cyt |
Recommended Dilution: | ELISA 1:5000-10000; Flow Cyt 1:100 |
Host Species: | Rabbit |
Isotype: | Rabbit IgG |
Reactivity: | Human |
Purification Method: | Purified from cell culture supernatant by affinity chromatography |
Formulation: | Powder |
Buffer: | 1XPBS |
Storage: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature. |
Usage: | Research use only |
Background: | This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25( )CD4( ) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |