Cell Biology Antibodies 12

Anti-GIPR Antibody (CAB9816)

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SKU:
CAB9816
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GIPR Antibody
Antibody SKU:CAB9816
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 22-138 of human GIPR (NP_000155.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:K-562, Mouse liver, Rat heart, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 22-138 of human GIPR (NP_000155.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RAET GSKG QTAG ELYQ RWER YRRE CQET LAAA EPPS GLAC NGSF DMYV CWDY AAPN ATAR ASCP WYLP WHHH VAAG FVLR QCGS DGQW GLWR DHTQ CENP EKNE AFLD QRLI LERL Q
Gene ID:2696
Uniprot:P48546
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:48kDa/49kDa/53kDa
Observed MW:45kDa
Synonyms:GIPR, PGQTL2
Background:This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.
UniProt Protein Function:GIPR: This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; GPCR, family 2; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: plasma membrane

Molecular Function:transmembrane receptor activity

Biological Process: adenylate cyclase activation; generation of precursor metabolites and energy; regulation of insulin secretion; response to nutrient

NCBI Summary:This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]
UniProt Code:P48546
NCBI GenInfo Identifier:1346133
NCBI Gene ID:2696
NCBI Accession:P48546.1
UniProt Secondary Accession:P48546,Q14401, Q16400, Q52M04, Q9UPI1, B7WP14, B7ZKQ0
UniProt Related Accession:P48546
Molecular Weight:49,062 Da
NCBI Full Name:Gastric inhibitory polypeptide receptor
NCBI Synonym Full Names:gastric inhibitory polypeptide receptor
NCBI Official Symbol:GIPR  
NCBI Official Synonym Symbols:PGQTL2  
NCBI Protein Information:gastric inhibitory polypeptide receptor
UniProt Protein Name:Gastric inhibitory polypeptide receptor
UniProt Synonym Protein Names:Glucose-dependent insulinotropic polypeptide receptor
Protein Family:Gastric inhibitory polypeptide receptor
UniProt Gene Name:GIPR  
UniProt Entry Name:GIPR_HUMAN
Anti-GIPR Polyclonal Antibody (CAB9816)Western blot analysis of extracts of various cell lines, using GIPR antibody (CAB9816) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s.
Anti-GIPR Polyclonal Antibody (CAB9816)Immunohistochemistry of paraffin-embedded rat brain using GIPR Rabbit pAb (CAB9816) at dilution of 1:200 (40x lens).
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