Cell Biology Antibodies 2
Anti-GIPC1 Antibody (CAB10550)
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- SKU:
- CAB10550
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GIPC1 Antibody |
| Antibody SKU: | CAB10550 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-333 of human GIPC1 (NP_005707.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, HeLa, HepG2, 293T, Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-333 of human GIPC1 (NP_005707.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MPLG LGRR KKAP PLVE NEEA EPGR GGLG VGEP GPLG GGGS GGPQ MGLP PPPP ALRP RLVF HTQL AHGS PTGR IEGF TNVK ELYG KIAE AFRL PTAE VMFC TLNT HKVD MDKL LGGQ IGLE DFIF AHVK GQRK EVEV FKSE DALG LTIT DNGA GYAF IKRI KEGS VIDH IHLI SVGD MIEA INGQ SLLG CRHY EVAR LLKE LPRG RTFT LKLT EPRK AFDM ISQR SAGG RPGS GPQL GTGR GTLR LRSR GPAT VEDL PSAF EEKA IEKV DDLL ESYM GIRD TELA ATMV ELGK DKRN PDEL AEAL DERL GDFA FPDE FVFD VWGA IGDA KVGR Y |
| Gene ID: | 10755 |
| Uniprot: | O14908 |
| Cellular Location: | Cytoplasm, Membrane, Peripheral membrane protein |
| Calculated MW: | 26kDa/36kDa |
| Observed MW: | 40kDa |
| Synonyms: | GIPC1, C19orf3, GIPC, GLUT1CBP, Hs.6454, IIP-1, NIP, RGS19IP1, SEMCAP, SYNECTIIN, SYNECTIN, TIP-2 |
| Background: |
| UniProt Protein Function: | GIPC1: May be involved in G protein-linked signaling. Belongs to the GIPC family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GAP; GAP, misc.; Motility/polarity/chemotaxis; Vesicle Chromosomal Location of Human Ortholog: 19p13.12 Cellular Component: cell cortex; cytoplasm; cytoplasmic vesicle; cytosol; dendritic shaft; dendritic spine; membrane; synaptic vesicle; vesicle membrane Molecular Function:actin binding; cadherin binding; myosin binding; protein binding; protein homodimerization activity; receptor binding Biological Process: endothelial cell migration; glutamate secretion; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of cytokinesis; positive regulation of transforming growth factor beta receptor signaling pathway; protein targeting; regulation of protein stability; regulation of synaptic plasticity; synaptic transmission |
| NCBI Summary: | GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008 [PubMed 18775991]).[supplied by OMIM, Apr 2009] |
| UniProt Code: | O14908 |
| NCBI GenInfo Identifier: | 17375873 |
| NCBI Gene ID: | 10755 |
| NCBI Accession: | O14908.2 |
| UniProt Secondary Accession: | O14908,Q9BTC9, A8K4I3, A8MZG3, |
| UniProt Related Accession: | O14908 |
| Molecular Weight: | 36kDa |
| NCBI Full Name: | PDZ domain-containing protein GIPC1 |
| NCBI Synonym Full Names: | GIPC PDZ domain containing family member 1 |
| NCBI Official Symbol: | GIPC1 |
| NCBI Official Synonym Symbols: | NIP; GIPC; IIP-1; TIP-2; SEMCAP; C19orf3; Hs.6454; GLUT1CBP; RGS19IP1; SYNECTIN; SYNECTIIN |
| NCBI Protein Information: | PDZ domain-containing protein GIPC1 |
| UniProt Protein Name: | PDZ domain-containing protein GIPC1 |
| UniProt Synonym Protein Names: | GAIP C-terminus-interacting protein; RGS-GAIP-interacting protein; RGS19-interacting protein 1; Synectin; Tax interaction protein 2; TIP-2 |
| Protein Family: | PDZ domain-containing protein |
| UniProt Gene Name: | GIPC1 |
 | Western blot analysis of extracts of various cell lines, using GIPC1 antibody (CAB10550) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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