Epigenetics & Nuclear Signaling Antibodies 4
Anti-GINS4 Antibody (CAB8592)
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- SKU:
- CAB8592
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-GINS4 Antibody |
| Antibody SKU: | CAB8592 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 108-207 of human GINS4 (NP_115712.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, 293T, HeLa, THP-1, Mouse thymus, Rat fat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 108-207 of human GINS4 (NP_115712.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LEKE KTRP EGEP SSLS PEEL AFAR EFMA NTES YLKN VALK HMPP NLQK VDLF RAVP KPDL DSYV FLRV RERQ ENIL VEPD TDEQ RDYV IDLE KGSQ HLIR |
| Gene ID: | 84296 |
| Uniprot: | Q9BRT9 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 11kDa/26kDa |
| Observed MW: | 26kDa |
| Synonyms: | GINS4, SLD5 |
| Background: |
| UniProt Protein Function: | GINS4: The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA. Belongs to the GINS4/SLD5 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 8p11.21 Cellular Component: nucleoplasm; cytoplasm Molecular Function:protein binding Biological Process: mitotic cell cycle; DNA strand elongation during DNA replication; inner cell mass cell proliferation |
| NCBI Summary: | The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9BRT9 |
| NCBI GenInfo Identifier: | 14150122 |
| NCBI Gene ID: | 84296 |
| NCBI Accession: | NP_115712.1 |
| UniProt Secondary Accession: | Q9BRT9,Q99LZ3, Q499W2, |
| UniProt Related Accession: | Q9BRT9 |
| Molecular Weight: | 11,844 Da |
| NCBI Full Name: | DNA replication complex GINS protein SLD5 |
| NCBI Synonym Full Names: | GINS complex subunit 4 (Sld5 homolog) |
| NCBI Official Symbol: | GINS4 |
| NCBI Official Synonym Symbols: | SLD5 |
| NCBI Protein Information: | DNA replication complex GINS protein SLD5; SLD5 homolog |
| UniProt Protein Name: | DNA replication complex GINS protein SLD5 |
| UniProt Synonym Protein Names: | GINS complex subunit 4DNA replication complex GINS protein SLD5, N-terminally processed |
| Protein Family: | DNA replication complex GINS protein |
| UniProt Gene Name: | GINS4 |
| UniProt Entry Name: | SLD5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GINS4 antibody (CAB8592) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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