Epigenetics & Nuclear Signaling Antibodies 4
Anti-GINS2 Antibody (CAB9172)
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- SKU:
- CAB9172
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-GINS2 Antibody |
| Antibody SKU: | CAB9172 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-185 of human GINS2 (NP_057179.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HeLa, Jurkat, MCF7, 22Rv1 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-185 of human GINS2 (NP_057179.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDAA EVEF LAEK ELVT IIPN FSLD KIYL IGGD LGPF NPGL PVEV PLWL AINL KQRQ KCRL LPPE WMDV EKLE KMRD HERK EETF TPMP SPYY MELT KLLL NHAS DNIP KADE IRTL VKDM WDTR IAKL RVSA DSFV RQQE AHAK LDNL TLME INTS GTFL TQAL NHMY KLRT NLQP LEST QSQD F |
| Gene ID: | 51659 |
| Uniprot: | Q9Y248 |
| Cellular Location: | Nucleus |
| Calculated MW: | 21kDa |
| Observed MW: | 21kDa |
| Synonyms: | GINS2, HSPC037, PSF2, Pfs2 |
| Background: |
| UniProt Protein Function: | PSF2: The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA. Belongs to the GINS2/PSF2 family. |
| UniProt Protein Details: | Protein type:DNA replication Chromosomal Location of Human Ortholog: 16q24.1 Cellular Component: nucleoplasm Molecular Function:3'-5' DNA helicase activity; protein binding Biological Process: DNA strand elongation during DNA replication; double-strand break repair via break-induced replication |
| NCBI Summary: | The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1 (GINS1; MIM 610608), Psf2, and Psf3 (GINS3; MIM 610610). The formation of this complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9Y248 |
| NCBI GenInfo Identifier: | 37999822 |
| NCBI Gene ID: | 51659 |
| NCBI Accession: | Q9Y248.1 |
| UniProt Secondary Accession: | Q9Y248,Q6IAG9, D3DUM5, |
| UniProt Related Accession: | Q9Y248 |
| Molecular Weight: | 21,428 Da |
| NCBI Full Name: | DNA replication complex GINS protein PSF2 |
| NCBI Synonym Full Names: | GINS complex subunit 2 |
| NCBI Official Symbol: | GINS2 |
| NCBI Official Synonym Symbols: | PSF2; Pfs2; HSPC037 |
| NCBI Protein Information: | DNA replication complex GINS protein PSF2 |
| UniProt Protein Name: | DNA replication complex GINS protein PSF2 |
| UniProt Synonym Protein Names: | GINS complex subunit 2 |
| Protein Family: | DNA replication complex GINS protein |
| UniProt Gene Name: | GINS2 |
| UniProt Entry Name: | PSF2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GINS2 antibody (CAB9172) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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