Cell Biology Antibodies 2

Anti-GIGYF2 Antibody (CAB12069)

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SKU:
CAB12069
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GIGYF2 Antibody
Antibody SKU:CAB12069
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 350-500 of human GIGYF2 (NP_001096617.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:1000 IHC 1:50 - 1:100
Reactivity:Human, Rat
Positive Samples:293T, HeLa, U-87MG?Jurkat, Raji, LO2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 350-500 of human GIGYF2 (NP_001096617.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VDEG EECS DSEG SHNE EAKE PDKT NKKE GEKT DRVG VASE ETPQ TSSS SARP GTPS DHQS QEAS QFER KDEP KTEQ TEKA EEET RMEN SLPA KVPS RGDE MVAD VQQP LSQI PSDT ASPL LILP PPVP NPSP TLRP VETP VVGA PGMG SVS
Gene ID:26058
Uniprot:Q6Y7W6
Cellular Location:
Calculated MW:148kDa/149kDa/150kDa/152kDa
Observed MW:190kDa
Synonyms:GIGYF2, GYF2, PARK11, PERQ2, PERQ3, TNRC15
Background:This gene contains CAG trinucleotide repeats and encodes a protein containing several stretches of polyglutamine residues. The encoded protein may be involved in the regulation of tyrosine kinase receptor signaling. This gene is located in a chromosomal region that was genetically linked to Parkinson disease type 11, and mutations in this gene were thought to be causative for this disease. However, more recent studies in different populations have been unable to replicate this association. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors.
NCBI Summary:This gene contains CAG trinucleotide repeats and encodes a protein containing several stretches of polyglutamine residues. The encoded protein may be involved in the regulation of tyrosine kinase receptor signaling. This gene is located in a chromosomal region that was genetically linked to Parkinson disease type 11, and mutations in this gene were thought to be causative for this disease. However, more recent studies in different populations have been unable to replicate this association. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
UniProt Code:Q6Y7W6
NCBI GenInfo Identifier:74710467
NCBI Gene ID:26058
NCBI Accession:Q6Y7W6.1
UniProt Secondary Accession:Q6Y7W6,O75137, Q7Z2Z8, Q7Z3I2, Q96HU4, Q9NV82, A6H8W4 B9EG55, E9PBB0,
UniProt Related Accession:Q6Y7W6
Molecular Weight:149,486 Da
NCBI Full Name:PERQ amino acid-rich with GYF domain-containing protein 2
NCBI Synonym Full Names:GRB10 interacting GYF protein 2
NCBI Official Symbol:GIGYF2  
NCBI Official Synonym Symbols:GYF2; PERQ2; PERQ3; PARK11; TNRC15  
NCBI Protein Information:PERQ amino acid-rich with GYF domain-containing protein 2
UniProt Protein Name:PERQ amino acid-rich with GYF domain-containing protein 2
UniProt Synonym Protein Names:GRB10-interacting GYF protein 2; Trinucleotide repeat-containing gene 15 protein
Protein Family:PERQ amino acid-rich with GYF domain-containing protein
UniProt Gene Name:GIGYF2  
UniProt Entry Name:PERQ2_HUMAN
Anti-GIGYF2 Antibody (CAB12069)Western blot analysis of extracts of various cell lines, using GIGYF2 antibody (CAB12069) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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