Cell Biology Antibodies 9

Anti-GGCT Antibody (CAB4957)

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SKU:
CAB4957
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
GGCT
Synonyms:
C7orf24
Synonyms:
CRF21
Synonyms:
GCTG
Synonyms:
GGC
Research Area:
Cell Biology

Description

Product Name:GGCT Rabbit pAb
Product Code:CAB4957
Size:20uL, 50uL, 100uL
Synonyms:GGCT, C7orf24, CRF21, GCTG, GGC
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-188 of human GGCT (NP_076956.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:293T, A-549, A-431
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-188 of human GGCT (NP_076956.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MANS GCKD VTGP DEES FLYF AYGS NLLT ERIH LRNP SAAF FCVA RLQD FKLD FGNS QGKT SQTW HGGI ATIF QSPG DEVW GVVW KMNK SNLN SLDE QEGV KSGM YVVI EVKV ATQE GKEI TCRS YLMT NYES APPS PQYK KIIC MGAK ENGL PLEY QEKL KAIE PNDY TGKV SEEI EDII KKGE TQTL
Gene ID:79017
Uniprot:O75223
Calculated MW:10kDa/12kDa/19kDa/21kDa
Observed MW:21kDa
UniProt Protein Function:GGCT: Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis. Belongs to the gamma-glutamylcyclotransferase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 2.3.2.4; Transferase; Apoptosis; Other Amino Acids Metabolism - glutathione

Chromosomal Location of Human Ortholog: 7p15-p14

Cellular Component: cytosol

Molecular Function:gamma-glutamylcyclotransferase activity; protein homodimerization activity

Biological Process: glutathione biosynthetic process; release of cytochrome c from mitochondria

NCBI Summary:The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
UniProt Code:O75223
NCBI GenInfo Identifier:34222503
NCBI Gene ID:79017
NCBI Accession:O75223.1
UniProt Secondary Accession:O75223,Q9BS37, B2RDN0, B8ZZN4, B8ZZR8,
UniProt Related Accession:O75223
Molecular Weight:19,092 Da
NCBI Full Name:Gamma-glutamylcyclotransferase
NCBI Synonym Full Names:gamma-glutamylcyclotransferase
NCBI Official Symbol:GGCT  
NCBI Official Synonym Symbols:GGC; GCTG; CRF21; C7orf24  
NCBI Protein Information:gamma-glutamylcyclotransferase
UniProt Protein Name:Gamma-glutamylcyclotransferase
UniProt Synonym Protein Names:Cytochrome c-releasing factor 21
Protein Family:Gamma-glutamylcyclotransferase
UniProt Gene Name:GGCT  
UniProt Entry Name:GGCT_HUMAN
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system_update_altDatasheetHuman GGCT Recombinant Protein Human ?-Glutamylcyclotransferase belongs to the Transferases family, specifically the Aminoacyltransferase. Gamma-Glutamylcyclotransferase