Metabolism Antibodies 2
Anti-GFM1 Antibody (CAB5077)
- SKU:
- CAB5077
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- GFM1
- Synonyms:
- COXPD1
- Synonyms:
- EFG
- Synonyms:
- EFG1
- Synonyms:
- EFGM
- Synonyms:
- EGF1
- Synonyms:
- GFM
- Synonyms:
- hEFG1
- Research Area:
- Metabolism
Description
| Product Name: | GFM1 Rabbit pAb |
| Product Code: | CAB5077 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | GFM1, COXPD1, EFG, EFG1, EFGM, EGF1, GFM, hEFG1 |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 482-751 of human GFM1 (NP_079272.4). |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 482-751 of human GFM1 (NP_079272.4). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VYFD TENK ETVI SGMG ELHL EIYA QRLE REYG CPCI TGKP KVAF RETI TAPV PFDF THKK QSGG AGQY GKVI GVLE PLDP EDYT KLEF SDET FGSN IPKQ FVPA VEKG FLDA CEKG PLSG HKLS GLRF VLQD GAHH MVDS NEIS FIRA GEGA LKQA LANA TLCI LEPI MAVE VVAP NEFQ GQVI AGIN RRHG VITG QDGV EDYF TLYA DVPL NDMF GYST ELRS CTEG KGEY TMEY SRYQ PCLP STQE DVIN KYLE ATGQ LPVK KGKA KN |
| Gene ID: | 85476 |
| Uniprot: | Q96RP9 |
| Cellular Location: | Mitochondrion |
| Calculated MW: | 83kDa/85kDa |
| Observed MW: | Refer to figures |
| UniProt Protein Function: | EFG1: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A- site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Defects in GFM1 are the cause of combined oxidative phosphorylation deficiency type 1 (COXPD1). It leads to early fatal progressive hepatoencephalopathy. Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Translation elongation; Mitochondrial; RNA-binding Chromosomal Location of Human Ortholog: 3q25 Cellular Component: mitochondrial matrix Molecular Function:GTPase activity; protein binding; GTP binding; translation elongation factor activity Biological Process: mitochondrial translation; organelle organization and biogenesis Disease: Combined Oxidative Phosphorylation Deficiency 1 |
| NCBI Summary: | Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96RP9 |
| NCBI GenInfo Identifier: | 116241346 |
| NCBI Gene ID: | 85476 |
| NCBI Accession: | Q96RP9.2 |
| UniProt Related Accession: | Q96RP9 |
| Molecular Weight: | |
| NCBI Full Name: | Elongation factor G, mitochondrial |
| NCBI Synonym Full Names: | G elongation factor mitochondrial 1 |
| NCBI Official Symbol: | GFM1 |
| NCBI Official Synonym Symbols: | EFG; GFM; EFG1; EFGM; EGF1; hEFG1; COXPD1; mtEF-G1 |
| NCBI Protein Information: | elongation factor G, mitochondrial |
| UniProt Protein Name: | Elongation factor G, mitochondrial |
| UniProt Synonym Protein Names: | Elongation factor G 1, mitochondrial; Elongation factor G1 |
| UniProt Gene Name: | GFM1 |
| UniProt Entry Name: | EFGM_HUMAN |
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