Cell Biology Antibodies 14

Anti-GFI1 Antibody (CAB16862)

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SKU:
CAB16862
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GFI1 Antibody
Antibody SKU:CAB16862
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GFI1 (NP_001120687.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse spleen, Rat thymus, Rat spleen
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GFI1 (NP_001120687.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MPRS FLVK SKKA HSYH QPRS PGPD YSLR LENV PAPS RADS TSNA GGAK AEPR DRLS PESQ LTEA PDRA SASP DSCE GSVC ERSS EFED FWRP PSPS ASPA
Gene ID:2672
Uniprot:Q99684
Cellular Location:
Calculated MW:45kDa
Observed MW:45kDa
Anti-GFI1 Antibody (CAB16862)Western blot - GFI1 Rabbit pAb (CAB16862)
Synonyms:GFI1, GFI-1, GFI1A, SCN2, ZNF163
Background:This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.
NCBI Summary:This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q99684
NCBI GenInfo Identifier:33860154
NCBI Gene ID:2672
NCBI Accession:Q99684.2
UniProt Related Accession:Q99684
Molecular Weight:
NCBI Full Name:Zinc finger protein Gfi-1
NCBI Synonym Full Names:growth factor independent 1 transcriptional repressor
NCBI Official Symbol:GFI1  
NCBI Official Synonym Symbols:SCN2; GFI-1; GFI1A; ZNF163  
NCBI Protein Information:zinc finger protein Gfi-1
UniProt Protein Name:Zinc finger protein Gfi-1
UniProt Synonym Protein Names:Growth factor independent protein 1; Zinc finger protein 163
Protein Family:Zinc finger protein
UniProt Gene Name:GFI1  
UniProt Entry Name:GFI1_HUMAN
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