Metabolism Antibodies 3

Anti-Gephyrin Antibody (CAB4729)

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SKU:
CAB4729
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
GEPH
Synonyms:
GPH
Synonyms:
GPHRYN
Synonyms:
HKPX1
Synonyms:
MOCODC
Research Area:
Metabolism

Description

Product Name:Gephyrin Rabbit mAb
Product Code:CAB4729
Size:20uL, 50uL, 100uL
Synonyms:GEPH, GPH, GPHRYN, HKPX1, MOCODC
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Gephyrin
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, HepG2, Mouse liver, Rat liver
Immunogen:A synthesized peptide derived from human Gephyrin
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10243
Uniprot:Q9NQX3
Cellular Location:Cell junction, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, cytoskeleton, postsynaptic cell membrane, synapse
Calculated MW:93kDa
Observed MW:93KDa
UniProt Protein Function:gephyrin: Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. Homotrimer. Interacts with GABARAP. Inhibited by copper and tungsten. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 2.7.7.75; Adaptor/scaffold; EC 2.10.1.1

Chromosomal Location of Human Ortholog: 14q23.3

Cellular Component: cytoplasm; dendrite; plasma membrane; postsynaptic membrane

Molecular Function:protein binding

Biological Process: Mo-molybdopterin cofactor biosynthetic process; molybdenum incorporation into molybdenum-molybdopterin complex; molybdopterin cofactor biosynthetic process

Disease: Hyperekplexia, Hereditary 1; Molybdenum Cofactor Deficiency, Complementation Group C

NCBI Summary:This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NQX3
NCBI GenInfo Identifier:13431554
NCBI Gene ID:10243
NCBI Accession:Q9NQX3.1
UniProt Secondary Accession:Q9NQX3,Q96KU4, Q9H4E9, Q9P2G2,
UniProt Related Accession:Q9NQX3
Molecular Weight:83,448 Da
NCBI Full Name:Gephyrin
NCBI Synonym Full Names:gephyrin
NCBI Official Symbol:GPHN  
NCBI Official Synonym Symbols:GPH; GEPH; HKPX1; GPHRYN; MOCODC  
NCBI Protein Information:gephyrin
UniProt Protein Name:Gephyrin
UniProt Synonym Protein Names:Domain E
Protein Family:Gephyrin
UniProt Gene Name:GPHN  
UniProt Entry Name:GEPH_HUMAN
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