Epigenetics & Nuclear Signaling Antibodies 2
Anti-GEMIN7 Antibody (CAB15189)
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- SKU:
- CAB15189
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-GEMIN7 Antibody |
| Antibody SKU: | CAB15189 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-131 of human GEMIN7 (NP_078983.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-131 of human GEMIN7 (NP_078983.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MQTP VNIP VPVL RLPR GPDG FSRG FAPD GRRA PLRP EVPE IQEC PIAQ ESLE SQEQ RARA ALRE RYLR SLLA MVGH QVSF TLHE GVRV AAHF GATD LDVA NFYV SQLQ TPIG VQAE ALLR CSDI ISYT FKP |
| Gene ID: | 79760 |
| Uniprot: | Q9H840 |
| Cellular Location: | Cytoplasm, Nucleus, gem, nucleoplasm |
| Calculated MW: | 14kDa |
| Observed MW: | 14kDa |
| Synonyms: | GEMIN7, SIP3 |
| Background: | The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear 'gems' (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. |
| UniProt Protein Function: | GEMIN7: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. Belongs to the gemin-7 family. |
| UniProt Protein Details: | Protein type:RNA splicing Chromosomal Location of Human Ortholog: 19q13.32 Cellular Component: cytoplasm; cytosol; nuclear body; nucleoplasm; nucleus; SMN complex Molecular Function:protein binding Biological Process: nuclear import; nuclear mRNA splicing, via spliceosome; spliceosomal snRNP biogenesis |
| NCBI Summary: | The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear "gems" (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9H840 |
| NCBI GenInfo Identifier: | 55953072 |
| NCBI Gene ID: | 79760 |
| NCBI Accession: | NP_001007270.1 |
| UniProt Secondary Accession: | Q9H840,Q6IA34, |
| UniProt Related Accession: | Q9H840 |
| Molecular Weight: | 41.9kD |
| NCBI Full Name: | gem-associated protein 7 |
| NCBI Synonym Full Names: | gem nuclear organelle associated protein 7 |
| NCBI Official Symbol: | GEMIN7 |
| NCBI Official Synonym Symbols: | SIP3 |
| NCBI Protein Information: | gem-associated protein 7 |
| UniProt Protein Name: | Gem-associated protein 7 |
| UniProt Synonym Protein Names: | SIP3 |
| Protein Family: | Gem-associated protein |
| UniProt Gene Name: | GEMIN7 |
 | Western blot analysis of extracts of HeLa cells, using GEMIN7 Rabbit pAb (CAB15189) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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