Epigenetics & Nuclear Signaling Antibodies 1

Anti-GEMIN6 Antibody (CAB12375)

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SKU:
CAB12375
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-GEMIN6 Antibody
Antibody SKU:CAB12375
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-167 of human GEMIN6 (NP_079051.9).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HT-29, HeLa, 293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-167 of human GEMIN6 (NP_079051.9).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSEW MKKG PLEW QDYI YKEV RVTA SEKN EYKG WVLT TDPV SANI VLVN FLED GSMS VTGI MGHA VQTV ETMN EGDH RVRE KLMH LFTS GDCK AYSP EDLE ERKN SLKK WLEK NHIP ITEQ GDAP RTLC VAGV LTID PPYG PENC SSSN EIIL SRVQ DLIE GHLT ASQ
Gene ID:79833
Uniprot:Q8WXD5
Cellular Location:Cytoplasm, Nucleus, gem, nucleoplasm
Calculated MW:18kDa
Observed MW:19kDa
Synonyms:GEMIN6
Background:
UniProt Protein Function:GEMIN6: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus.
UniProt Protein Details:

Protein type:RNA splicing

Chromosomal Location of Human Ortholog: 2p22.1

Cellular Component: cytoplasm; cytosol; nuclear body; nucleoplasm; SMN complex

Molecular Function:protein binding

Biological Process: nuclear import; nuclear mRNA splicing, via spliceosome; spliceosomal snRNP biogenesis

NCBI Summary:GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM, Jul 2002]
UniProt Code:Q8WXD5
NCBI GenInfo Identifier:34921901
NCBI Gene ID:79833
NCBI Accession:Q8WXD5.1
UniProt Secondary Accession:Q8WXD5,Q53SI5, Q8WVB4, Q9H5G6, B2RDP8,
UniProt Related Accession:Q8WXD5
Molecular Weight:19kDa
NCBI Full Name:Gem-associated protein 6
NCBI Synonym Full Names:gem nuclear organelle associated protein 6
NCBI Official Symbol:GEMIN6  
NCBI Protein Information:gem-associated protein 6
UniProt Protein Name:Gem-associated protein 6
UniProt Synonym Protein Names:SIP2
Protein Family:Gem-associated protein
UniProt Gene Name:GEMIN6  
Anti-GEMIN6 Antibody (CAB12375)Western blot analysis of extracts of various cell lines, using GEMIN6 antibody (CAB12375) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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