Epigenetics & Nuclear Signaling Antibodies 1
Anti-GEMIN4 Antibody (CAB10764)
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- SKU:
- CAB10764
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-GEMIN4 Antibody |
| Antibody SKU: | CAB10764 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-350 of human GEMIN4 (NP_056536.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, MCF7, SH-SY5Y, Jurkat, Mouse brain, Mouse kidney, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-350 of human GEMIN4 (NP_056536.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LREI SSAA AHSQ PFAW KKKA LIII WAKV LQPH PVTP SDTE TRWQ EDLF FSVG NMIP TINH TILF ELLK SLEA SGLF IQLL MALP TTIC HAEL ERFL EHVT VDTS AEDV AFFL DVWW EVMK HKGH PQDP LLSQ FSAM AHKY LPAL DEFP HPPK RLRS DPDA CPTM PLLA MLLR GLTQ IQSR ILGP GRKC CALA NLAD MLTV FALT EDDP QEVS ATVY LDKL ATVI SVWN SDTQ NPYH QQAL AEKV KEAE RDVS LTSL AKLP SETI FVGC EFLH HLLR EWGE ELQA VLRS SQGT SYDS YRLC D |
| Gene ID: | 50628 |
| Uniprot: | P57678 |
| Cellular Location: | Cytoplasm, Nucleus, gem, nucleolus |
| Calculated MW: | 120kDa |
| Observed MW: | 120kDa |
| Synonyms: | GEMIN4, HC56, HCAP1, HHRF-1, p97 |
| Background: | The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. |
| UniProt Protein Function: | GEMIN4: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. |
| UniProt Protein Details: | Protein type:Nucleolus; RNA splicing; RNA-binding Chromosomal Location of Human Ortholog: 17p13.3 Cellular Component: cytoplasm; cytosol; membrane; nuclear body; nucleoplasm; small nuclear ribonucleoprotein complex; SMN complex Molecular Function:protein binding Biological Process: nuclear import; spliceosomal snRNP biogenesis |
| NCBI Summary: | The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P57678 |
| NCBI GenInfo Identifier: | 322510030 |
| NCBI Gene ID: | 50628 |
| NCBI Accession: | P57678.2 |
| UniProt Secondary Accession: | P57678,Q9NZS7, Q9UG32, Q9Y4Q2, |
| UniProt Related Accession: | P57678 |
| Molecular Weight: | 120kDa |
| NCBI Full Name: | Gem-associated protein 4 |
| NCBI Synonym Full Names: | gem nuclear organelle associated protein 4 |
| NCBI Official Symbol: | GEMIN4 |
| NCBI Official Synonym Symbols: | p97; HC56; HCAP1; HHRF-1 |
| NCBI Protein Information: | gem-associated protein 4 |
| UniProt Protein Name: | Gem-associated protein 4 |
| UniProt Synonym Protein Names: | Component of gems 4; p97 |
| Protein Family: | Gem-associated protein |
| UniProt Gene Name: | GEMIN4 |
 | Western blot analysis of extracts of various cell lines, using GEMIN4 antibody (CAB10764) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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