Cell Biology Antibodies 9
Anti-GDI1 Antibody (CAB5462)
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- SKU:
- CAB5462
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GDI1 Antibody |
| Antibody SKU: | CAB5462 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 188-447 of human GDI1 (NP_001484.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T, SH-SY5Y, HT-29, Jurkat, A-549, M21, Mouse spleen, Mouse brain, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 188-447 of human GDI1 (NP_001484.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ALAL YRTD DYLD QPCL ETVN RIKL YSES LARY GKSP YLYP LYGL GELP QGFA RLSA IYGG TYML NKPV DDII MENG KVVG VKSE GEVA RCKQ LICD PSYI PDRV RKAG QVIR IICI LSHP IKNT NDAN SCQI IIPQ NQVN RKSD IYVC MISY AHNV AAQG KYIA IAST TVET TDPE KEVE PALE LLEP IDQK FVAI SDLY EPID DGCE SQVF CSCS YDAT THFE TTCN DIKD IYKR MAGT AFDF ENMK RKQN DVFG EAEQ |
| Gene ID: | 2664 |
| Uniprot: | P31150 |
| Cellular Location: | Cytoplasm, Golgi apparatus, trans-Golgi network |
| Calculated MW: | 50kDa |
| Observed MW: | 60kDa |
| Synonyms: | GDI1, 1A, GDIL, MRX41, MRX48, OPHN2, RABGD1A, RABGDIA, XAP-4 |
| Background: | GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific mental retardation. |
| UniProt Protein Function: | GDI1: a GDP dissociation inhibitor protein expressed primarily in neural and sensory tissues. GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the Rab family, small GTP-binding proteins of the Ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from Rab proteins and release GDP from membrane-bound Rabs. Mutations have been linked to X-linked nonspecific mental retardation. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; G protein regulator, misc. Chromosomal Location of Human Ortholog: Xq28 Cellular Component: Golgi apparatus; neuron projection; protein complex; cytoplasm; midbody; cytosol Molecular Function:protein binding; GDP-dissociation inhibitor activity; Rab GDP-dissociation inhibitor activity; GTPase activator activity; Rab GTPase binding Biological Process: protein transport; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; negative regulation of axonogenesis; signal transduction; Rab protein signal transduction; response to calcium ion; positive regulation of GTPase activity Disease: Mental Retardation, X-linked 41 |
| NCBI Summary: | GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific mental retardation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P31150 |
| NCBI GenInfo Identifier: | 1707886 |
| NCBI Gene ID: | 2664 |
| NCBI Accession: | P31150.2 |
| UniProt Secondary Accession: | P31150,P50394, Q6FG50, Q7Z2G6, Q7Z2G9, Q7Z2H5, Q7Z2I6 |
| UniProt Related Accession: | P31150 |
| Molecular Weight: | 447 |
| NCBI Full Name: | Rab GDP dissociation inhibitor alpha |
| NCBI Synonym Full Names: | GDP dissociation inhibitor 1 |
| NCBI Official Symbol: | GDI1 |
| NCBI Official Synonym Symbols: | 1A; GDIL; MRX41; MRX48; OPHN2; XAP-4; RABGD1A; RABGDIA |
| NCBI Protein Information: | rab GDP dissociation inhibitor alpha; GDI-1; protein XAP-4; rab GDI alpha; oligophrenin-2; mental retardation, X-linked 48; rab GDP-dissociation inhibitor, alpha; guanosine diphosphate dissociation inhibitor 1 |
| UniProt Protein Name: | Rab GDP dissociation inhibitor alpha |
| UniProt Synonym Protein Names: | Guanosine diphosphate dissociation inhibitor 1; GDI-1; Oligophrenin-2; Protein XAP-4 |
| Protein Family: | Guanosine nucleotide diphosphate dissociation inhibitor |
| UniProt Gene Name: | GDI1 |
| UniProt Entry Name: | GDIA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GDI1 antibody (CAB5462) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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